Results 81 to 90 of about 3,938,305 (341)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Identifying Environmental Risk Factors and Mapping the Distribution of West Nile Virus in an Endemic Region of North America

GeoHealth, 2018
Understanding the geographic distribution of mosquito‐borne disease and mapping disease risk are important for prevention and control efforts. Mosquito‐borne viruses (arboviruses), such as West Nile virus (WNV), are highly dependent on environmental ...
A. Hess, J. K. Davis, M. C. Wimberly
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Modeling Airborne Influenza in Three Dimensions

Engineering Reports
Spatial differences in how people live and move are key to understanding how flu spreads, but many traditional models ignore these details, making it harder to predict real‐world outbreaks.
Daniel Ugochukwu Nnaji, Omeh Chinenye, Gabriel Chinedu Nnaji, Samuel Onuche John, Nnaemeka Stanley Aguegboh   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Modelling Framework to Estimate Vector Dispersal and Disease Spread in an Important Agricultural Pathosystem

Journal of Sustainable Agriculture and Environment
Cereal aphids vector devastating cereal pathogens, primarily yellow dwarf viruses, with severe infection reducing yields by 20%–80%. Several aphid species are of concern in cereal agro‐ecosystems, and farmers are currently advised to apply insecticide if
Katharine F. Preedy, Louise Mc Namara, Md Munir Mostafiz, Maximilian Schughart, Lawrence E. Bramham, Daniel J. Leybourne   +5 more
doaj   +1 more source

Spatial dynamics and convergence: the spatial AK model [PDF]

We study the optimal dynamics of an AK economy where population is uniformly distributed along the unit circle. Locations only differ in initial capital endowments. Despite constant returns to capital, we prove that transition dynamics will set in.
Carmen CAMACHO, Giorgio FABBRI, Raouf BOUCEKKINE   +2 more
core  

Spatial Models

, 2017
Since the turn of the century, the interest for spatial models in marketing science has increased significantly. An econometric model becomes spatial if the behavior of one economic agent is codetermined by the dependent variable, the explanatory variables, and/or the error term observed on other economic agents, known as respectively the spatially ...
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source