Results 61 to 70 of about 292,599 (242)

Signals, tracks, and trams: public transport signal priority impact on job accessibility over time

Scientific Reports
Improving travel time by public transport is a major task for city planners and policy makers to increase its competitiveness relative to cars which can be facilitated by implementing public transport preferential infrastructure treatments such as signal
Michał A. Niedzielski, Sławomir Goliszek, Anna Górka   +2 more
doaj   +1 more source

Chironomid- and pollen-based quantitative climate reconstructions for the post-Holsteinian (MIS 11b) in Central Europe [PDF]

Climate of the Past
Investigating climatic and environmental changes during past interglacials is crucial to improve our understanding of the mechanisms that govern changes related to current global warming.
T. Polkowski, A. Gruszczyńska, A. Gruszczyńska, B. Kotrys, A. Górecki, A. Hrynowiecka, M. Żarski, M. Błaszkiewicz, J. Nitychoruk, M. Czajkowska, S. Lauterbach, S. Lauterbach, M. Słowiński   +12 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Tourism space: an attempt at a fresh look

Tourism, 2014
In this article, the author is trying to answer the fundamental question: what is present-day tourism space like at a time of highly increasing flows of people or even a shift from the space of a ‘place’ to the space of a ‘flow’? The article puts special
Marek Więckowski
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Headquarters of Large Enterprises in the Spatial Structure of Major Polish Cities

Prace Komisji Geografii Przemysłu Polskiego Towarzystwa Geograficznego, 2014
The paper is based on the author’s monograph (Śleszyński, 2008). It presents the analysis of enterprise headquarters’ locations in eight largest Polish cities (Warsaw, Szczecin, The Tricity [Gdańsk–Gdynia–Sopot], Poznań, Łódź, Wrocław, Katowice and ...
Przemysław Śleszyński
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source