Results 81 to 90 of about 19,086 (267)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Efficient Indexing Method for Massive 3D Geological Block Models Based on Inverted-B＋ Tree [PDF]

Jisuanji kexue
The prevalence of zero or null values in three-dimensional geological block models raises maintenance costs and efficiency issues due to frequent splitting and adjustment of the B＋tree-based attribute index structure.An indexing method based on Inverted ...
CHEN Genshen, LIU Gang, DONG Yang, FAN Wenyao, YI Qiang, JIANG Zixin
doaj   +1 more source

Spatial Queries in the Presence of Obstacles

, 2004
Despite the existence of obstacles in many database applications, traditional spatial query processing utilizes the Euclidean distance metric assuming that points in space are directly reachable. In this paper, we study spatial queries in the presence of obstacles, where the obstructed distance between two points is defined as the length of the ...
Jun Zhang 0005, Dimitris Papadias, Kyriakos Mouratidis, Manli Zhu   +3 more
openaire   +3 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

A novel multi-objective SKG-skyline algorithm integrating spatial keyword data transformation

Complex & Intelligent Systems
The spatial keyword skyline query effectively addresses user preferences, particularly for location-based service applications. However, existing approaches primarily focus on single-object queries and remain unsuitable for group-based computations.
Xiaowei Cui, Leigang Dong, Guohao Sun, Yuanjun Huang, Yixuan Chai, Quan Yu   +5 more
doaj   +1 more source

A Privacy‐Preserving Spatial Index for Spatial Query Processing

Wireless Communications and Mobile Computing, 2018
An increasing amount of active research is being conducted to protect the locations of mobile device users. Users must tune to more data than they would like to in order to hide their location. In particular, if a user requests a query over k NN, the number of objects the user must receive ...
Doohee Song, MoonBae Song, Kwangjin Park
openaire   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source