Results 61 to 70 of about 8,060,684 (303)
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Measuring ecosystem multifunctionality across scales
Multifunctionality refers to the capacity of an area to supply multiple ecosystem functions or services. While many conceptual and methodological advances have focused on defining and quantifying multifunctionality, the challenge of dealing with cross ...
Lisanne Hölting +6 more
doaj +1 more source
Disaster resilience describes the ability of a community to bounce back from disaster impacts by resilience building activities. Social media provides an innovative way to observe human attitudes and responses, especially during disasters.
Kejin Wang +2 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Percolation Analysis – Archaeological Applications at Widely Different Spatial Scales
This paper provides a summary of the percolation method of cluster analysis, and then describes two detailed archaeological case studies where the technique is applied at significantly different geographical scales.
M. Simon Maddison, Sophie C. Schmidt
doaj +1 more source
Spatial coding for action across spatial scales
Humans perform goal-directed actions such as reaching for a light switch or grasping a coffee mug thousands of times a day. Behind the scenes of these seemingly simple actions, the brain performs sophisticated calculations to locate the target object of the action and correctly guide the hand towards it.
Fiehler, Katja +2 more
openaire +3 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Factors affecting Bobolink nest survival across grassland types
Grassland birds, including Bobolinks (Dolichonyx oryzivorus), have experienced steep population declines across their breeding range in North America. Because of these declines, Bobolinks were listed as threatened by the Ontario and Canadian governments.
Monica A. Fromberger +5 more
doaj
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source

