Results 41 to 50 of about 1,471,906 (260)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Spatial scan statistics for matched case-control data.
PLoS ONE, 2019 Spatial scan statistics are widely used for cluster detection analysis in geographical disease surveillance. While this method has been developed for various types of data such as binary, count, and continuous data, spatial scan statistics for matched ...
Inkyung Jung
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Geosciences, 2020 Landscape archaeology has a long history of using predictive models to improve our knowledge of extant archaeological features around the world. Important advancements in spatial statistics, however, have been slow to enter archaeological predictive ...
Dylan S. Davis +2 more
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Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Factors Differentiating Poles’ Attitudes Towards Social Relations – a Spatial Approach
Acta Universitatis Lodziensis. Folia Oeconomica, 2019 The research focuses on Poles’ attitudes towards selected aspects associated with social relations. Responses to the following 6 statements were examined: 1 – People try to help others above all, 2 – Homosexuals should be allowed to live according to ...
Tomasz Szubert
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A Simple Spatial Method for Identifying Point Clusters by Neighbourhood Relationships
Ecologies, 2021 Point events can be distributed regularly, randomly, or in clusters. A cluster of points is defined by the distance from which any point included in a cluster is farther from any other point outside the cluster. Many solutions and methods are possible to
Neftalí Sillero
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, 2013 This paper addresses the problem of recovering the spatial market potential of a retail product from spatially distributed sales data. In order to tackle the problem in a general way, the concept of spatial potential is introduced.
Finazzi, Francesco
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Rectangular Hierarchical Cartograms for Socio-Economic Data [PDF]
, 2010 We present rectangular hierarchical cartograms for mapping socio-economic data. These density-normalising cartograms size spatial units by population, increasing the ease with which data for densely populated areas can be visually resolved compared to ...
Aidan Slingsby +9 more
core +2 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Analysis of Drought Spatial Statistics in Iran [PDF]
تحقیقات کاربردی علوم جغرافیایی, 2019 Drought is one of the environmental events and an inseparable part of climatic fluctuations. This phenomenon is one of the main characteristics of the various climates. Awareness of spatiotemporal behavior is effective in land planning.
saeed javizadeh, zahra hejazizadeh
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