Results 41 to 50 of about 323,364 (251)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

MEAN VALUES FOR HOMOGENEOUS STIT TESSELLATIONS IN 3D

open access: yesImage Analysis and Stereology, 2011
Recently (Nagel and Weiss, 2005), the class of homogeneous random tessellations that are stable under the operation of iteration (STIT) was introduced. In the present paper this model is reviewed and new results for the mean values of essential geometric
Werner Nagel, Viola Weiss
doaj   +1 more source

Spatial Study of Enzymatic Activities from Bacterial Isolates in a Mediterranean Urban Park

open access: yesLand, 2023
Urban parks are a rich source of microbial diversity, as they are heavily used by city residents. In this study, we sampled a Mediterranean park and were able to isolate bacteria that have the ability to inhibit the growth of control microorganisms.
Sergi Maicas, Jaume Segura-Garcia
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

MGWR: A Python Implementation of Multiscale Geographically Weighted Regression for Investigating Process Spatial Heterogeneity and Scale

open access: yesISPRS International Journal of Geo-Information, 2019
Geographically weighted regression (GWR) is a spatial statistical technique that recognizes that traditional ‘global’ regression models may be limited when spatial processes vary with spatial context.
Taylor M. Oshan   +4 more
doaj   +1 more source

Comparing Bayesian Spatial Conditional Overdispersion and the Besag–York–Mollié Models: Application to Infant Mortality Rates

open access: yesMathematics, 2021
In this paper, we review overdispersed Bayesian generalized spatial conditional count data models. Their usefulness is illustrated with their application to infant mortality rates from Colombian regions and by comparing them with the widely used Besag ...
Mabel Morales-Otero   +1 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Social Networks and Social Cohesion in the Netherlands: Insights from Combined Administrative and Survey Data

open access: yesSocial Sciences
Statistics Netherlands (CBS) has recently developed the whole population network (Person Network) file, based on administrative microdata, which includes over a billion interpersonal relationships among approximately 17 million inhabitants of the ...
Dino Pitoski, Hans Schmeets
doaj   +1 more source

Spatial Wavelet Statistics of SAR Backscatter for Characterizing Degraded Forest: A Case Study From Cameroon

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2015
Forest degradation is an important issue in global environmental studies, albeit not yet well defined in quantitative terms. The present work addresses the problem, by starting with the assumption that forest spatial structure can provide an indication ...
Elsa C. De Grandi   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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