Results 41 to 50 of about 16,214,189 (289)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
LOCAL ARTISANS’ KNOWLEDGE OF FLOOD RESILIENT CONSTRUCTION AND ADAPTATION OF RESIDENTIAL BUILDINGS IN FLOOD-PRONE INFORMAL SETTLEMENTS IN DAR ES SALAAM, TANZANIA [PDF]
Central European Journal of Geography and Sustainable Development, 2023 Flood-prone informal settlements are among the most complex and challenging construction sites that require adequate knowledge to enhance flood resilience and adaptation. While such settlements present construction challenges that need the attention of
Emmanuel Fares Kemwita +3 more
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2008 This brochure documents the interdisciplinary breadth of the spatial perspective for research and teaching. Although this argument focuses on UC Santa Barbara, it could be easily documented for nearly all institutions of highter ...
Center for Spatial Studies, UCSB
core +1 more source
Indicators for evaluating European population health: a Delphi selection process
BMC Public Health, 2018 Background Indicators are essential instruments for monitoring and evaluating population health. The selection of a multidimensional set of indicators should not only reflect the scientific evidence on health outcomes and health determinants, but also ...
Ângela Freitas +5 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Spatial Lightning Talks Overview [PDF]
, 2015 This document introductes the Spatial Lightning Talks, an annual event at the University of California, Santa Barbara, that brings together an interdisciplinary panel of speakers.
Center for Spatial Studies
core +1 more source
European Journal of Geography, 2015 Population health is influenced by complex interactions between multiple determinants, but there are still large gaps in knowledge about how to comprehensively evaluate the impact of these factors on health.
Paula SANTANA +3 more
doaj +2 more sources
Rainfall analysis in mountain streams affected by torrential floods on Madeira Island, Portugal [PDF]
Natural Hazards and Earth System SciencesTorrential floods are powerful and destructive events that result from a mix of debris and water moving rapidly down steep channels in mountainous areas. They are normally triggered by heavy rainfall.
S. Lopes, M. Fragoso, E. Reis
doaj +1 more source