Results 51 to 60 of about 16,214,189 (289)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Imagine a Nation of Spatial Thinkers [PDF]
, 2008 This brochure seeks to broaden public understanding for the importance of spatial literacy for solving problems in science and for ...
Center for Spatial Studies, UCSB
core +1 more source
Scientific ReportsThe delineation of the Wildland-Urban Interface (WUI) is fundamental for wildfire risk management, yet it is highly sensitive to the underlying building data used.
Bruno Barbosa +3 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Spatial Interactions in Hedonic Pricing Models: The Urban Housing Market of Aveiro, Portugal [PDF]
, 2011 Spatial heterogeneity, spatial dependence and spatial scale constitute key features of spatial analysis of housing markets. However, the common practice of modelling spatial dependence as being generated by spatial interactions through a known spatial ...
Bhattacharjee, Arnab +6 more
core +2 more sources
Mapping Long-Term Wildfire Dynamics in Portugal Using Trajectory Analysis (1975–2024)
LandWildfire regimes in Mediterranean landscapes are becoming increasingly unpredictable, driven by the combined effects of climate change, land-use transitions, and socio-economic pressures.
Bruno Barbosa +3 more
doaj +1 more source
Air Pollution and Emergency Hospital Admissions—Evidences from Lisbon Metropolitan Area, Portugal
Applied Sciences, 2020 The relevance of air pollution in the public health agenda has recently been reinforced—it is known that exposure to it has negative effects in the health of individuals, especially in big cities and metropolitan areas.
Pedro Franco +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Strategies to heat mitigation during future extreme heat stress conditions in Lisbon, Portugal
Discover SustainabilityThis study assesses projected future thermal comfort conditions and the impact of Human Based Solutions (HBS) on heat stress mitigation, in a known hotspot in Lisbon.
Tiago Silva +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source