Results 101 to 110 of about 4,913,721 (332)

Multiscale Soil Investigations: Physical Concepts And Mathematical Techniques [PDF]

, 2008
Soil variability has often been considered to be composed of “functional” (explained) variations plus random fl uctuations or noise. However, the distinction between these two components is scale dependent because increasing the scale of ...
A. M. Tarquis, Blank, Burrough, Burrough, Cheng, Coops, E. Perfect, Earls, Eghball, García Moreno, Heuvelink, Hopmans, Kravchenko, Kravchenko, Lin, Lovejoy, McBratney, Pachepsky, Pachepsky, Papadopoulos, S. D. Logsdon, Si, Sommer, Svoraya, Tang, Tarquis, Vereecken, Vidal Vázquez, Western, Zamora-Castro, Zhang, Zhang   +31 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Variation in Soil Carbon Dioxide Efflux at Two Spatial Scales in a Topographically Complex Boreal Forest [PDF]

, 2012
Carbon dynamics of high latitude regions are an important and highly uncertain component of global carbon budgets, and efforts to constrain estimates of soil-atmosphere carbon exchange in these regions are contingent on accurate representations of ...
Kelsey, Katharine C, Neff, Jason C, Striegl, Robert G, Wickland, Kimberly P   +3 more
core   +3 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Computational system for geostatistical analysis

Scientia Agricola, 2004
Geostatistics identifies the spatial structure of variables representing several phenomena and its use is becoming more intense in agricultural activities.
Laurimar Gonçalves Vendrusculo, Paulo Sérgio Graziano Magalhães, Sidney Rosa Vieira, José Ruy Porto de Carvalho   +3 more
doaj  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

ASSESSING SPATIAL BREAK-EVEN VARIABILITY IN FIELDS WITH TWO OR MORE MANAGEMENT ZONES [PDF]

Farmers are interested in knowing whether applying inputs at variable rates across a field is economically viable. The answer depends on the crop, the input, their prices, the cost of variable rate technology (VRT) versus uninform rate technology (URT ...
English, Burton C., Mahajanashetti, S.B., Roberts, Roland K.   +2 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Exploring the variability and geographical patterns of population characteristics: Regional and spatial perspectives

Moravian Geographical Reports, 2017
The variability and geographical patterns of population characteristics are key topics in Human Geography. There are many approaches to exploring and quantitatively measuring this issue.
Netrdová Pavlína, Nosek Vojtěch
doaj   +1 more source