Results 71 to 80 of about 4,617,927 (260)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Spatial variation in functional group diversity in a sandflat benthic community: implications for ecosystem resilience [PDF]

, 2013
The resilience of macrobenthic communities to environmental stress depends upon the vulnerability, adaptability and connectivity of species. Recent studies suggest that the function(s) species perform may be more influential in driving community response
Greenfield, Barry Leon
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Reproductive performance links to fine-scale spatial patterns of female grey seal relatedness [PDF]

, 2001
Fine–scale spatial patterns of female relatedness throughout the established grey seal breeding colony of North Rona, Scotland, were investigated by accurate mapping and spatially explicit analyses of a large sample (n=262) of mothers using variation at ...
P. P. Pomeroy, S. D. Twiss, Worthington Wilmer, J., Worthington Wilmer, J, Pomeroy, Patrick, Amos, W, W. Amos, Pomeroy, P.P., J. Worthington Wilmer, Amos, W., Twiss, S.D., Twiss, SD   +11 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Spatial variation in burrow entrance density of the sooty shearwater (Puffinus griseus)

, 2014
The effects of a range of habitat variables on spatial variation of breeding burrow density of sooty shearwaters, Puffinus griseus, were measured on 5 islands near Rakiura (Stewart Is) and 1 island in The Snares Is group, during the 2000-01 breeding ...
Knight, Ben, Charleton, Kristin, Moller, Henrik, Newman, Jamie, Scott, Darren, Bragg, Corey, Fletcher, David   +6 more
core   +1 more source

Monitoring of Vegetation Drought Index in Laibin City Based on Landsat Multispectral Remote Sensing Data

Applied Sciences
Due to the impact of global warming, drought has caused serious damage to China’s ecological environment and social status. This article selects Laibin City in the Guangxi Zhuang Autonomous Region as the research area, utilizing multispectral remote ...
Xiangsuo Fan, Yan Zhang, Lin Chen, Peng Li, Qi Li, Xueqiang Zhao   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A geostatistical analysis of the spatial variation of soil mineral nitrogen and potentially available nitrogen within an arable field.

, 2003
The technology for site-specific applications of nitrogen (N) fertilizer has exposed a gap in our knowledge about the spatial variation of soil mineral N, and that which will become available during the growing season within arable fields. Spring mineral
Baxter, S. J., Baxter, S.J., Oliver, M.A., Gaunt, J., Gaunt, J. L., Oliver, M. A.   +5 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source