Results 51 to 60 of about 39,296 (293)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Pigment dispersal across variable anisotropic flow fields.
, 2022 (a) Four Hele-Shaw cell states with spatially-varied outlet boundary conditions. (b) Estimated (idealized) steady-state potential flow field from cell configurations in a. (c) Overlaid time-series images demonstrating anisotropic droplet growth over time.
Raphael Kay (12279887) +3 more
core +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Experimental and Numerical Study of Vacuum Resin Infusion for Thin-Walled Composite Parts
Applied Sciences, 2020 This paper considers a new approach to the modeling of the vacuum infusion process at the manufacturing of three-dimensional composite parts of complex shape.
Sergey Shevtsov +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
HT-FED2004-56069 DIFFERENCE FORMULATION AND SLOPE INVARIANCE IN SPATIALLY VARIED FREE SURFACE FLOW
, 2020 The relationship for combined increasing and decreasing free surface flow is presented in difference form, and then particularized to spatially increasing and spatially decreasing flows.
S David Graber
core
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Controls on runoff generation and scale-dependence in a distributed hydrologic model [PDF]
Hydrology and Earth System Sciences, 2007 Hydrologic response in natural catchments is controlled by a set of complex interactions between storm properties, basin characteristics and antecedent wetness conditions.
E. R. Vivoni +3 more
doaj
Importance of neutral processes varies in time and space: Evidence from dryland stream ecosystems.
PLoS ONE, 2017 Many ecosystems experience strong temporal variability in environmental conditions; yet, a clear picture of how niche and neutral processes operate to determine community assembly in temporally variable systems remains elusive.
Xiaoli Dong +4 more
doaj +1 more source