Results 151 to 160 of about 21,277,776 (188)

Increased soluble programmed death-1 (sPD-1) is associated with disease activity and radiographic progression in early rheumatoid arthritis

Scandinavian Journal of Rheumatology, 2013
Programmed death-1 (PD-1) is an immunoregulatory molecule functioning by down-regulating immune responses. PD-1 is present on follicular helper T cells (TFH) and is important in the formation of plasma cells. PD-1 exists in a bioactive soluble form (sPD-1) and is thought to be implicated in disease activity in chronic rheumatoid arthritis (RA).We ...
Greisen, S R, Rasmussen, T K, Stengaard-Pedersen, K, Hetland, M L, Hørslev-Petersen, K, Hvid, M, Deleuran, B   +6 more
openaire   +4 more sources

Serum sPD-1 and sPD-L1 as Biomarkers for Evaluating the Efficacy of Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Patients

Clinical Breast Cancer, 2019
Neoadjuvant chemotherapy (NAC) is widely administered in the primary treatment of triple-negative breast cancer (TNBC). However, serum biomarkers for evaluating or monitoring the curative efficacy of NAC have not been established. Accumulating data have shown that soluble programmed death 1 (sPD-1) and its ligand (sPD-L1) might be potential biomarkers ...
Yao, Li, Xiang, Cui, Yong-Jun, Yang, Qing-Qiu, Chen, Ling, Zhong, Ting, Zhang, Rui-Li, Cai, Jing-Ya, Miao, Shi-Cang, Yu, Fan, Zhang   +9 more
openaire   +2 more sources

Regulating immunity and inhibiting tumor growth by the recombinant peptide sPD-1-CH50.

Anticancer research, 2010
Soluble programmed death-1 (sPD-1) has been proven to bind PD-1 ligands (PD-Ls), block PD-L/PD-1 interactions, and enhance the cytolysis of cytotoxic T-lymphocytes (CTLs). CH50, a two-domain molecule of fibronectin, has been shown to suppress the development of tumors via enhancing the activity of macrophages.
Hui, Qiu, Shaoping, Liu, Conghua, Xie, Jian, Long, Zuohua, Feng   +4 more
openaire   +1 more source

Blockade of B7-H1 with sPD-1 improves immunity against murine hepatocarcinoma.

Anticancer research, 2005
The B7-H1/PD-1 pathway has been demonstrated to be involved in tumor evasion. In a previous study, we constructed a eukaryotic expression plasmid (pPD-1A), which expresses soluble PD-1 (sPD-1). In this study, the question of whether or not the blockade of B7-H1 with sPD-1 in vivo and vitro can improve antitumor immunity was investigated.The ...
Lanxiang, He, Guimei, Zhang, Yufei, He, Hangang, Zhu, Hui, Zhang, Zuohua, Feng   +5 more
openaire   +1 more source

High serum sPD-1 and sPD-L1 levels 1 predict outcome in hepatocellular carcinoma patients treated with radiotherapy.

Journal of Clinical Oncology, 2020
e16672 Background: Accumulating data have shown that soluble (s)PD-1 and sPD-L1 are potential biomarkers for the curative efficacy of chemotherapy in several cancers. However, these markers have not been well established for outcomes in hepatocellular carcinoma (HCC) radiotherapy (RT).
Shisuo Du, Genwen Chen, Yixing Chen, Ping Yang, Yong Hu, Qianqian Zhao, Zhao-Chong Zeng   +6 more
openaire   +1 more source

[Therapeutic effects of simultaneous expression of 4-1BBL and sPD-1 on experimental murine hepatoma].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2010
To explore the possible negative regulatory elements induced by the treatment of experimental murine hepatoma with 4-1BBL, and to investigate the synergistic effects and mechanisms of 4-1BBL and soluble PD-1 (sPD-1) in tumor therapy.Mice were inoculated intramuscularly (i.m.) with 5 x 10(5) H22 tumor cells in the right hind thigh to establish the ...
Hui, Qiu, Hui, Zhang, Zuo-hua, Feng, Hui, Geng, Gui-mei, Zhang   +4 more
openaire   +1 more source

Levels of sPD-L1 and sPD-1 in Women with Toxoplasma Gondii Infection and Ovarian Cancer in Thi-Qar

Клиническая инфектология и паразитология
Toxoplasma gondii is a protozoan parasite that affects humans worldwide. It may influence immune responses and increase complications in cancer patients. Many studies referred relationship between T. gondii infection and ovarian cancer, therefor this study aimed to evaluate the possible effects of T. gondii infection on ovarian cancer through affecting
A.M. Zainab, S.M. Zahraa
openaire   +1 more source

OVERALL SURVIVAL RATES IN RENAL CELL CARCINOMA PATIENTS AND SERUM sPD-1 AND sPD-L1 LEVELS

Problems of Biological, Medical and Pharmaceutical Chemistry
Introduction. Renal cell carcinoma (RCC) is one of the most aggressive tumors of the urinary system. Immune checkpoints such as PD-1 and PD-L1 play an important role in regulating the antitumor immune response. Serum levels of soluble forms of PD-1 (sPD-1) and PD-L1 (sPD-L1) may have some clinical significance in RCC, but their prognostic value remains
N. Sokolov, O. Kovaleva, S. Bezhanova, I. Babkina, V. Matveev, N. Kushlinskii   +5 more
openaire   +1 more source

Enhanced HIV-1 Gag-specific immunity induced by a sPD-1-based vaccine directed to dendritic cells (53.23)

The Journal of Immunology, 2011
Abstract HIV/AIDS is a serious disease worldwide. The development of a safe, effective and affordable HIV-1 vaccine remains the ultimate solution. This study is based on the discovery of a negative immune regulatory system, the PD-1/PD-L pathway, which exists on both human and other animals.
Jingying Zhou, Haibo Wang, Zhiwu Tan, Yanhua Du, Zhiwei Chen   +4 more
openaire   +1 more source

Prognostic value of soluble programmed cell death-1 (sPD-1) and soluble programmed cell death ligand-1 (sPD-L1) for hepatocellular carcinoma: a systematic review and meta-analysis

Cancer Immunology, Immunotherapy, 2021
Jun-Shuai Xue, Lun-Jie Yan, Hai-Chao Li   +2 more
exaly