Results 81 to 90 of about 11,363,089 (416)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Augmented reality in special education: a meta-analysis of single-subject design studies

open access: yesEuropean Journal of Special Needs Education, 2019
There is a growing interest in using augmented reality (AR) applications to support individuals with special needs, such as intellectual disabilities, autism spectrum disorder, attention deficit hyperactivity disorder, and physical disabilities.
R. Baragash   +3 more
semanticscholar   +1 more source

Students With Disabilities and California's Special Education Program [PDF]

open access: yes, 2009
Provides an overview of the state's special education programs, including eligibility, enrollment, student performance, time spent outside regular classrooms, spending, and financing, compared to national trends.
Stephen Lipscomb
core  

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

Promoting Open Science to Increase the Trustworthiness of Evidence in Special Education

open access: yesThe Exceptional Child, 2018
Scientific evidence should guide the selection of practice for individuals with disabilities. Scientific evidence, however, must be trustworthy to move special education toward greater empirical certainty and more effective policies and practices ...
Bryan G. Cook   +4 more
semanticscholar   +1 more source

Chang, Ji-Mei [PDF]

open access: yes, 2018
University of Southern California, Department of Curriculum, Teaching, & Special Education, 1989, Ph.D. University of Southern California, School of Education, 1978, M.S.
San Jose State University
core   +1 more source

Provision for students with learning difficulties in general colleges of further education - have we been going round in circles? [PDF]

open access: yes, 2006
This is a PDF version of an article published in British journal of special education© 2006. The definitive version is available at www.blackwell-synergy.com.This article discusses the current situation for students with severe learning difficulties in ...
Ainley   +31 more
core   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

Special Education

open access: yesDefinitions, 2020
Our mission is to prepare educators to work with children, youth and adults with disabilities to be academically and socially successful lifelong learners.
Linda Forbringer
semanticscholar   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

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