Results 81 to 90 of about 4,266,161 (351)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

From similarity to conceptual—how pictophonetic Chinese characters facilitate inductive reasoning in 5–10-year-old children

open access: yesFrontiers in Psychology
IntroductionInductive reasoning develops from similarity-based to category-based processes, and linguistic labels are thought to facilitate this shift, though whether they provide similarity or conceptual information remains debated.MethodsTo clarify the
Xiaoxi Wang   +4 more
doaj   +1 more source

Parent opinions on the individualisation of education of children with autism spectrum disorders at schools

open access: yesSpecialusis Ugdymas, 2020
The article examines the opinions of parents raising children with ASD about the individualisation of their children's education at schools. A theoretical analysis of the relevance of the partnership of parents raising children with ASD with teachers ...
Živilė Kulešė, Irena Kaffemanienė
doaj   +1 more source

On the pulse of change: the new beat of special education in higher education [PDF]

open access: yes, 2010
The roles and responsibilities of special educators in both special and regular school settings are changing rapidly. More than two decades ago the move towards more inclusive practices disrupted the traditional, niche separatism of special educators to
  +2 more
core   +3 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Right to inclusive education for children with disabilities at stake in Lithuania

open access: yesSpecialusis Ugdymas, 2020
Since 2010 Lithuania is a State Party of the Convention on the Rights of Persons with Disabilities of the United Nations. The development of education policy in Lithuania as concerns the right to inclusive education for children with disabilities is ...
Jonas Ruškus
doaj   +1 more source

Chang, Ji-Mei [PDF]

open access: yes, 2018
University of Southern California, Department of Curriculum, Teaching, & Special Education, 1989, Ph.D. University of Southern California, School of Education, 1978, M.S.
San Jose State University
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

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