Results 91 to 100 of about 1,164,136 (338)

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

open access: yesMolecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran   +16 more
wiley   +1 more source

Propensity score methodology in the presence of network entanglement between treatments [PDF]

open access: yesarXiv, 2018
In experimental design and causal inference, it may happen that the treatment is not defined on individual experimental units, but rather on pairs or, more generally, on groups of units. For example, teachers may choose pairs of students who do not know each other to teach a new curriculum; regulators might allow or disallow merging of firms, and ...
arxiv  

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

open access: yesMolecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa   +13 more
wiley   +1 more source

A Czech Morphological Lexicon [PDF]

open access: yesProceedings of the Third Meeting of the ACL Special Interest Group in Computational Phonology, pp. 41-47, Madrid, July 1997. ACL, 1997
In this paper, a treatment of Czech phonological rules in two-level morphology approach is described. First the possible phonological alternations in Czech are listed and then their treatment in a practical application of a Czech morphological lexicon.
arxiv  

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu   +7 more
wiley   +1 more source

On the Canonical Treatment of Lagrangian Constraints [PDF]

open access: yesarXiv, 2001
The canonical treatment of dynamic systems with manifest Lagrangian constraints proposed by Berezin is applied to concrete examples: a special Lagrangian linear in velocities, relativistic particles in proper time gauge, a relativistic string in orthonormal gauge, and the Maxwell field in the Lorentz gauge,
arxiv  

Special Considerations in the Treatment of Pregnancy Rhinitis [PDF]

open access: yesWomen's Health, 2005
Pregnancy rhinitis is a common condition that is not yet fully recognized by the public. This form of rhinitis affects approximately one in five pregnant women, can start in almost any gestational week, and disappears after delivery. However, as it reduces quality of life, and also possibly affects the fetus, treatment is often required.
openaire   +2 more sources

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

open access: yesMolecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock   +10 more
wiley   +1 more source

Anticancer activity of novel oleanolic acid methyl ester derivative in HeLa cervical cancer cells is mediated through apoptosis induction and reactive oxygen species production

open access: yesBangladesh Journal of Pharmacology, 2015
The objective of this study was to determine the anticancer and apoptotic effects of a novel oleanolic acid methyl vanillate derivative in human cervical cancer cells (HeLa).
Xin Song   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy