Results 101 to 110 of about 4,019,418 (288)

Berberine protects against hypoxia-induced intestinal injury through modulation of gut microbiota and bile acid metabolism

Frontiers in Immunology
BackgroundHigh-altitude hypoxia disrupts intestinal homeostasis by impairing the epithelial barrier, triggering inflammation, and promoting microbial translocation. Berberine (BER), a natural isoquinoline alkaloid with antimicrobial and anti-inflammatory
Hao Zhang, Hao Zhang, Hao Zhang, Penghui Ye, Penghui Ye, Penghui Ye, Wenlong Yang, Wenlong Yang, Wenlong Yang, Yuanyuan Dou, Yuanyuan Dou, Yuanyuan Dou, Zhenhao Tian, Zhenhao Tian, Zhenhao Tian, Nu Zhang, Nu Zhang, Nu Zhang, Ning Cui, Ning Cui, Ning Cui, Leming Sun, Leming Sun, Leming Sun, Zhuoyi Liu, Yijia Chen, Xiru Liu, Hui Yang, Hui Yang, Hui Yang   +29 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A Novel Nomogram for Predicting Warfarin-Related Bleeding: A Retrospective Cohort Study

Clinical and Applied Thrombosis/Hemostasis
Warfarin is a widely used anticoagulant, and bleeding complications are the main reason why patients discontinue the drug. Currently, there is no nomogram model for warfarin-associated bleeding risk. The aim of this study was to develop a risk-prediction
Shaohua Yang MD, Wensen Yao MD
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Nonlinear relationship between blood urea nitrogen to albumin ratio and in-hospital mortality in non-diabetic patients with non-ST-segment elevation myocardial infarction

Frontiers in Nutrition
BackgroundThe blood urea nitrogen (BUN) to albumin (ALB) ratio (BAR) is a novel biomarker that reflects both nutritional and inflammatory status and has been linked to the prognosis of various acute and chronic diseases.
Lixia Yuan, Wensen Yao
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Not Just a Fish Killer: Multi-Organ Toxicity and Mechanisms of 6PPD-Quinone

Toxics
6PPD-Quinone (6PPD-Q) is a tire derivative formed by the oxidation of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), a commonly used antioxidant and ozone stabilizer in rubber products, and has emerged as a significant environmental concern ...
Pinzhi Dong, Meijun Liu, Haiyan Wang, Jin Chen, Xiaorong Xu, Hailong Su, Ming Qin, Junmin Luo   +7 more
doaj   +1 more source

Special Treatment Everywhere, Special Treatment Nowhere

, 2015
This symposium essay disputes the conventional wisdom that “special treatment” mandates are exceptional within employment discrimination jurisprudence. To the contrary, they are endemic, and necessarily so. This is true even within disparate treatment jurisprudence. The reasons are twofold.
openaire   +2 more sources

Bible Theory or Biblical Living: What are Christian Schools Providing for Families With Children With Special Needs?

, 2009
Private Christian elementary and secondary schools, along with Bible training and Bible exercises, have been a part of the United States and international community since the 1800s.
Ramirez, A.Y. Fred , Ph.D.
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source