Results 101 to 110 of about 11,747,696 (301)

KÜLÖNLEGES BÁNÁSMÓD, 2016. 2. (4.)

, 2016
Special Treatment, 2016. Vol. 2. (4.) - full textKülönleges Bánásmód, 2016. 2.
Special, Treatment, Különleges, Bánásmód   +1 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Advances in nanomaterial-based delivery systems for inducing transplantation tolerance

Frontiers in Immunology
Organ transplantation is the primary therapeutic approach for patients with end-stage organ failure. However, challenges such as transplant rejection, the toxic side effects of long-term systemic immunosuppression, and substantial economic burdens remain
Qingqing Li, Yun Zhang, Jinwei Wu, Dongxing Huang, Zhongquan Qi, Zhongquan Qi   +5 more
doaj   +1 more source

ON THE SPECIAL STUDY AND TREATMENT OF PHTHISIS. [PDF]

The Lancet
n ...
openaire   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Surgical myectomy might inhibit ascending aortic dilation in obstructive hypertrophic cardiomyopathy: a serial cardiac magnetic resonance study

Journal of Cardiothoracic Surgery
Background The impact of septal myectomy on the progression of ascending aortic (AAo) dilation in patients with obstructive hypertrophic cardiomyopathy (HOCM) remains uncertain. This study aimed to investigate the relationship between septal myectomy and
Changpeng Song, Xinli Guo, Xinxin Zheng, Jie Lu, Jingang Cui, Shuiyun Wang, Xiaohong Huang   +6 more
doaj   +1 more source

Funding vaccines for emerging infectious diseases

Human Vaccines & Immunotherapeutics, 2018
Immunization has played a large role in substantially reducing the infected and death tolls from infectious diseases. In the case of emerging diseases, the identity of the pathogen responsible, as well as the time and location for the next outbreak ...
Gary Wong, Xiangguo Qiu
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Myocardial bridging in obstructive hypertrophic cardiomyopathy: a risk factor for myocardial fibrosis

BMC Medicine
Background Myocardial bridging (MB) is common in patients with hypertrophic cardiomyopathy (HCM). There are sparse data on the impact of MB on myocardial fibrosis in HCM.
Changpeng Song, Shengwei Wang, Xinli Guo, Manyun Huang, Xinxin Zheng, Jie Lu, Keshan Ji, Shihua Zhao, Jingang Cui, Shuiyun Wang, Xiaohong Huang   +10 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source