Results 101 to 110 of about 1,228,724 (306)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Surgical myectomy might inhibit ascending aortic dilation in obstructive hypertrophic cardiomyopathy: a serial cardiac magnetic resonance study

Journal of Cardiothoracic Surgery
Background The impact of septal myectomy on the progression of ascending aortic (AAo) dilation in patients with obstructive hypertrophic cardiomyopathy (HOCM) remains uncertain. This study aimed to investigate the relationship between septal myectomy and
Changpeng Song, Xinli Guo, Xinxin Zheng, Jie Lu, Jingang Cui, Shuiyun Wang, Xiaohong Huang   +6 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

ON THE SPECIAL STUDY AND TREATMENT OF PHTHISIS. [PDF]

The Lancet
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openaire   +2 more sources

Continued need for special treatment

BMJ, 1998
It is not known how many survivors there are from the war in the Far East. Of the 61 000 allied prisoners taken at Singapore all but between 13 000 and 16 000 survived compared with the very high mortality among native slave labourers. This was due largely to the discipline of the men and the remarkable effectiveness of the medical corps working in ...
openaire   +3 more sources

Myocardial bridging in obstructive hypertrophic cardiomyopathy: a risk factor for myocardial fibrosis

BMC Medicine
Background Myocardial bridging (MB) is common in patients with hypertrophic cardiomyopathy (HCM). There are sparse data on the impact of MB on myocardial fibrosis in HCM.
Changpeng Song, Shengwei Wang, Xinli Guo, Manyun Huang, Xinxin Zheng, Jie Lu, Keshan Ji, Shihua Zhao, Jingang Cui, Shuiyun Wang, Xiaohong Huang   +10 more
doaj   +1 more source

Decoding autoimmune disease with single-cell immune repertoire and transcriptome sequencing: mechanisms and therapeutic opportunities

Frontiers in Immunology
Autoimmune diseases result from a breakdown of immune tolerance, driving the aberrant activation and clonal expansion of self-reactive T and B cells. Progress has been limited by the inability to link clonal identity to functional states at single-cell ...
Shuqing Wang, Shuqing Wang, Zhao Dong, Zhao Dong, Yuefang Liu, Yuefang Liu, Xianhe Ren, Xianhe Ren, Xin Wang, Xin Wang, Hongsong Yu, Hongsong Yu   +11 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A Novel Nomogram for Predicting Warfarin-Related Bleeding: A Retrospective Cohort Study

Clinical and Applied Thrombosis/Hemostasis
Warfarin is a widely used anticoagulant, and bleeding complications are the main reason why patients discontinue the drug. Currently, there is no nomogram model for warfarin-associated bleeding risk. The aim of this study was to develop a risk-prediction
Shaohua Yang MD, Wensen Yao MD
doaj   +1 more source

Berberine protects against hypoxia-induced intestinal injury through modulation of gut microbiota and bile acid metabolism

Frontiers in Immunology
BackgroundHigh-altitude hypoxia disrupts intestinal homeostasis by impairing the epithelial barrier, triggering inflammation, and promoting microbial translocation. Berberine (BER), a natural isoquinoline alkaloid with antimicrobial and anti-inflammatory
Hao Zhang, Hao Zhang, Hao Zhang, Penghui Ye, Penghui Ye, Penghui Ye, Wenlong Yang, Wenlong Yang, Wenlong Yang, Yuanyuan Dou, Yuanyuan Dou, Yuanyuan Dou, Zhenhao Tian, Zhenhao Tian, Zhenhao Tian, Nu Zhang, Nu Zhang, Nu Zhang, Ning Cui, Ning Cui, Ning Cui, Leming Sun, Leming Sun, Leming Sun, Zhuoyi Liu, Yijia Chen, Xiru Liu, Hui Yang, Hui Yang, Hui Yang   +29 more
doaj   +1 more source