Results 61 to 70 of about 2,949,493 (224)

Protective Potential of Maresins in Cardiovascular Diseases

Frontiers in Cardiovascular Medicine, 2022
Cardiovascular diseases are the leading causes of global mortality. Growing evidence suggests that unresolved inflammation contributes to the chronicity, progression and morbidity of many cardiovascular diseases, thus emphasizing the urgent need to ...
Min Liu, Huixiang He, Lihong Chen
doaj   +1 more source

The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza

Frontiers in Physiology, 2021
In this review, we discuss spatiotemporal kinetics and inflammatory signatures of innate immune cells specifically found in response to SARS-CoV-2 compared to influenza virus infection. Importantly, we cover the current understanding on the mechanisms by
Sabina Sahanic, Judith Löffler-Ragg, Piotr Tymoszuk, Richard Hilbe, Egon Demetz, Rebecca K Masanetz, Markus Theurl, Johannes Holfeld, Can Gollmann-Tepeköylü, Alexandar Tzankov, Guenter Weiss, Martin Giera, Ivan Tancevski   +12 more
doaj   +1 more source

From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution

Acta Pharmaceutica Sinica B, 2021
Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory reaction. Lipid mediators orchestrate both the initiation and resolution of inflammation.
Tran Thi Van Anh, Alilou Mostafa, Zhigang Rao, Simona Pace, Stefan Schwaiger, Christian Kretzer, Veronika Temml, Carsten Giesel, Paul M. Jordan, Rossella Bilancia, Christina Weinigel, Silke Rummler, Birgit Waltenberger, Tran Hung, Antonietta Rossi, Hermann Stuppner, Oliver Werz, Andreas Koeberle   +17 more
doaj   +1 more source

Resolvins, Specialized Pro-Resolving Lipid Mediators and their Potential Roles in Metabolic Diseases

Cell Metabolism, 2013
Inflammation is associated with development of diseases characterized by altered nutrient metabolism. While an acute inflammatory response is host-protective and normally self-limited, chronic low-grade inflammation associated with metabolic diseases is ...
Matthew Spite, J. Clària, C. Serhan
semanticscholar   +1 more source

Specialized Pro-Resolving Lipid Mediators in the Inflammatory Response: An Update

Biochimica et Biophysica Acta, 2010
A new genus of specialized pro-resolving mediators (SPM) which include several families of distinct local mediators (lipoxins, resolvins, protectins, and maresins) are actively involved in the clearance and regulation of inflammatory exudates to permit ...
G. Bannenberg, C. Serhan
semanticscholar   +1 more source

Differential impact of 5-lipoxygenase-activating protein antagonists on the biosynthesis of leukotrienes and of specialized pro-resolving mediators

Frontiers in Pharmacology, 2023
Lipoxygenases (LOX) transform arachidonic acid (AA, C20:4) and docosahexaenoic acid (DHA, C22:6) into bioactive lipid mediators (LMs) that comprise not only pro-inflammatory leukotrienes (LTs) but also the specialized pro-resolving mediators (SPMs) that ...
Philipp Dahlke, Lukas K. Peltner, Paul M. Jordan, Paul M. Jordan, Oliver Werz, Oliver Werz   +5 more
doaj   +1 more source

Altered Tissue Specialized Pro-Resolving Mediators in Chronic Rhinosinusitis

, 2021
Current literature implicates arachidonic acid-derived leukotrienes and prostaglandins in the pathogenesis of chronic rhinosinusitis. However, other omega-3 and omega-6 derived lipid mediators, such as specialized pro-resolving mediators (SPMs), may also
Kroehl, Miranda E., Armstrong, Michael, Vickery, Thad W., Reisdorph, Nichole A., Ramakrishnan, Vijay R., Robertson, Charles E., Kofonow, Jennifer M., Frank, Daniel N.   +7 more
core   +1 more source

Modulation of Inflammation-Related Lipid Mediator Pathways by Celastrol During Human Macrophage Polarization

Journal of Inflammation Research, 2022
Kehong Zhang,1,2 Paul Mike Jordan,1 Simona Pace,1 Robert K Hofstetter,1 Markus Werner,1 Xinchun Chen,2 Oliver Werz1 1Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena, D-07743, Germany ...
Zhang K, Jordan PM, Pace S, Hofstetter RK, Werner M, Chen X, Werz O   +6 more
doaj  

Impaired Resolution of Inflammation in Alzheimer’s Disease: A Review

Frontiers in Immunology, 2017
Alzheimer’s disease (AD) remains the leading cause of dementia worldwide, and over the last several decades, the role of inflammation in the pathogenesis of this neurodegenerative disorder has been increasingly elucidated.
Robert A. Whittington, Emmanuel Planel, Emmanuel Planel, Niccolò Terrando   +3 more
doaj   +1 more source

Quantitative profiling of inflammatory and pro-resolving lipid mediators in human adolescents and mouse plasma using UHPLC-MS/MS [PDF]

, 2021
Objectives Lipid mediators are bioactive lipids which help regulate inflammation. We aimed to develop an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method to quantify 58 pro-inflammatory and pro-resolving lipid ...
Osuna, Ester; https://orcid.org/, Hartling, Ivan; https://orcid.org/, Lou, Phing-How; https://orcid.org/, Cremonesi, Alessio; https://orcid.org/, Lucchinetti, Eliana; https://orcid.org/, Zaugg, Michael; https://orcid.org/, Hersberger, Martin; https://orcid.org/   +6 more
core   +1 more source