Results 1 to 10 of about 2,369,325 (253)

Specialized Pro-Resolving Lipid Mediators: Endogenous Roles and Pharmacological Activities in Infections

Molecules, 2023
During an infection, inflammation mobilizes immune cells to eliminate the pathogen and protect the host. However, inflammation can be detrimental when exacerbated and/or chronic.
Fernanda S. Rasquel-Oliveira, Matheus Deroco Veloso da Silva, Geovana Martelossi-Cebinelli, Victor Fattori, Rubia Casagrande, Waldiceu A. Verri   +5 more
doaj   +2 more sources

Specialized Pro-Resolving Mediators Mitigate Cancer-Related Inflammation: Role of Tumor-Associated Macrophages and Therapeutic Opportunities [PDF]

Frontiers in Immunology, 2021
Inflammation is a fundamental physiological response orchestrated by innate immune cells to restore tissue homeostasis. Specialized pro-resolving mediators (SPMs) are involved in active resolution of inflammation but when inflammation is incomplete ...
Margot Lavy, Vanessa Gauttier, Nicolas Poirier, Sophie Barillé-Nion, Christophe Blanquart   +4 more
doaj   +2 more sources

Specialized Pro-resolving Lipid Mediators and Glial Cells: Emerging Candidates for Brain Homeostasis and Repair

Frontiers in Cellular Neuroscience, 2021
Astrocytes and oligodendrocytes are known to play critical roles in the central nervous system development, homeostasis and response to injury. In addition to their well-defined functions in synaptic signaling, blood-brain barrier control and myelination,
Marta Tiberi, Valerio Chiurchiù, Valerio Chiurchiù   +2 more
doaj   +1 more source

Human and Mouse Eosinophils Differ in Their Ability to Biosynthesize Eicosanoids, Docosanoids, the Endocannabinoid 2-Arachidonoyl-glycerol and Its Congeners

Cells, 2022
High eosinophil (EOS) counts are a key feature of eosinophilic asthma. EOS notably affect asthmatic response by generating several lipid mediators. Mice have been utilized in hopes of defining new pharmacological targets to treat asthma.
Anne-Sophie Archambault, Julyanne Brassard, Émilie Bernatchez, Cyril Martin, Vincenzo Di Marzo, Michel Laviolette, Louis-Philippe Boulet, Marie-Renée Blanchet, Nicolas Flamand   +8 more
doaj   +1 more source

The Protectin Family of Specialized Pro-resolving Mediators: Potent Immunoresolvents Enabling Innovative Approaches to Target Obesity and Diabetes

Frontiers in Pharmacology, 2019
A western type diet and lifestyle play an important role in the development of chronic diseases, yet little insight into the precise cellular and biomolecular mechanisms has emerged. It is known that an unbalanced diet may result in obesity and diabetes.
Trond Vidar Hansen, Anders Vik, Charles N. Serhan   +2 more
doaj   +1 more source

Maresin 1 Exerts a Tissue-Specific Regulation of Adipo-Hepato-Myokines in Diet-Induced Obese Mice and Modulates Adipokine Expression in Cultured Human Adipocytes in Basal and Inflammatory Conditions

Biomolecules, 2023
This study analyses the effects of Maresin 1 (MaR1), a docosahexaenoic acid (DHA)-derived specialized proresolving lipid mediator with anti-inflammatory and insulin-sensitizing actions, on the expression of adipokines, including adiponectin, leptin ...
Leyre Martínez-Fernández, Miguel Burgos, Neira Sáinz, Laura M. Laiglesia, José Miguel Arbones-Mainar, Pedro González-Muniesa, María J. Moreno-Aliaga   +6 more
doaj   +1 more source

A novel therapeutic strategy of obesity from the perspective of SPMs [PDF]

Exploration of Endocrine and Metabolic Diseases
The global prevalence of obesity and type 2 diabetes mellitus (T2DM)—the most common metabolic disorders—has reached epidemic proportions over the past half-century, with obesity being a key driver of insulin resistance and T2DM development.
Ze-Wei Zhao
doaj   +1 more source

Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201

Journal of Inflammation Research, 2022
Christian Kretzer,1 Paul M Jordan,1 Rossella Bilancia,2 Antonietta Rossi,2 Tuğçe Gür Maz,3 Erden Banoglu,3 Ulrich S Schubert,4,5 Oliver Werz1,5 1Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University
Kretzer C, Jordan PM, Bilancia R, Rossi A, Gür Maz T, Banoglu E, Schubert US, Werz O   +7 more
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Treatment With a Marine Oil Supplement Alters Lipid Mediators and Leukocyte Phenotype in Healthy Patients and Those With Peripheral Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Peripheral artery disease (PAD) is an advanced form of atherosclerosis characterized by chronic inflammation. Resolution of inflammation is a highly coordinated process driven by specialized pro‐resolving lipid mediators endogenously derived ...
Melinda S. Schaller, Mian Chen, Romain A. Colas, Thomas A. Sorrentino, Ann A. Lazar, S. Marlene Grenon, Jesmond Dalli, Michael S. Conte   +7 more
doaj   +1 more source

Development of an Optimized LC-MS Method for the Detection of Specialized Pro-Resolving Mediators in Biological Samples

Frontiers in Pharmacology, 2019
The cardioprotective and anti-inflammatory effects of long chain omega-3 polyunsaturated fatty acids (n3 PUFA) are believed to be partly mediated by their oxygenated metabolites (oxylipins).
Laura Kutzner, Katharina M. Rund, Annika I. Ostermann, Nicole M. Hartung, Jean-Marie Galano, Laurence Balas, Thierry Durand, Michael S. Balzer, Sascha David, Nils Helge Schebb   +9 more
doaj   +1 more source