Results 41 to 50 of about 2,369,325 (253)

Specialized Pro-resolving Mediators: Resolving Inflammation and Restoring Bone [PDF]

, 2023
Periodontitis is a chronic inflammatory disease characterized by gingival inflammation and loss of periodontal ligament attachment, which if severe enough can lead to the irreversible destruction of surrounding alveolar bone.
Tran, Amber, Raglin, Amber, Bilbrey, Carrie Nichole   +2 more
core   +1 more source

Specialized Pro-Resolving Lipid Mediators in Cystic Fibrosis [PDF]

International Journal of Molecular Sciences, 2018
In cystic fibrosis (CF), impaired airway surface hydration (ASL) and mucociliary clearance that promote chronic bacterial colonization, persistent inflammation, and progressive structural damage to the airway wall architecture are typically explained by ion transport abnormalities related to the mutation of the gene coding for the Cystic Fibrosis ...
Réginald Philippe, Valerie Urbach
openaire   +3 more sources

Specialized pro-resolving mediator network: an update on production and actions [PDF]

Essays in Biochemistry, 2020
Abstract Today, persistent and uncontrolled inflammation is appreciated to play a pivotal role in many diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic syndrome and many other diseases of public health concern (e.g. Coronavirus Disease 2019 (COVID-19) and periodontal disease). The ideal response to initial
Chiang, Nan, Serhan, Charles N.
openaire   +2 more sources

Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch. [PDF]

Annu Rev Pharmacol Toxicol, 2023
Specialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins, are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty acids during the acute phase or resolution phase of inflammation. Synthetic SPMs possess broad safety profiles and exhibit potent actions in resolving inflammation in ...
Ji RR.
europepmc   +3 more sources

Application of specialized pro-resolving mediators in periodontitis and peri-implantitis: a review. [PDF]

Eur J Oral Sci, 2021
AbstractScaling and root planning is a key element in the mechanical therapy used for the eradication of biofilm, which is the major etiological factor for periodontitis and peri‐implantitis. However, periodontitis is also a host mediated disease, therefore, removal of the biofilm without adjunctive therapy may not achieve the desired clinical outcome ...
Ali M, Yang F, Plachokova AS, Jansen JA, Walboomers XF.   +4 more
europepmc   +5 more sources

Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far? [PDF]

, 2022
peer reviewedFormation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic acid 12- and 15-lipoxygenating paralogues (15-LO1 ...
Geisslinger, Gerd, Kühn, Hartmut, Rund, K. M., Kühn, H., O'Donnell, V. B., O'Donnell, V., Rohwer, N., Dahlgren, Claes,, FitzGerald, G.A., Kahnt, A. S., Schebb, N.H., Alnouri, M., O'Donnell, Valerie B., Jakobsson, P., FitzGerald, G., Murphy, Robert C., Geisslinger, G., O'Donnell, Valerie B, Flamand, Nicolas, Weylandt, Karsten-Henrich, O’Donnell, V.B., Murphy, Robert C, Rund, K., Murphy, R., Alnouri, Mohamad Wessam, FitzGerald, Garret A., Kahnt, Astrid S., Weylandt, K., Flamand, N., Hanson, J., Alnouri, M.W., O’Donnell, Valerie B., Schebb, N., FitzGerald, Garret A, Offermanns, S., Jakobsson, P. J., Murphy, R.C., Dahlgren, C., Steinhilber, D., Alnouri, M. W., Weylandt, K.H., Dahlgren, Claes, Kuehn, H., Peters-Golden, Marc, Kahnt, A.S., Kahnt, Astrid Stefanie, Offermanns, Stefan, Schebb, N. H., Rund, Katharina M, Weylandt, Karsten H., Rund, K.M., Jakobsson, P.J., Weylandt, Karsten H, Rund, Katharina M., Kahnt, A., Schebb, Nils Helge, Murphy, R. C., Jakobsson, Per-Johan, Kahnt, Astrid S, Peters-Golden, M., FitzGerald, G. A., Rohwer, Nadine, Hanson, Julien, Weylandt, K. H., Steinhilber, Dieter   +64 more
core   +1 more source

Role and mechanism of specialized pro-resolving mediators in obesity-associated insulin resistance. [PDF]

Lipids Health Dis
With the changing times, obesity has become a characteristic epidemic in the context of the current era. Insulin resistance (IR) is most commonly caused by obesity, and IR is a common basis of the pathogenesis of many diseases such as cardiovascular ...
Liu X, Tang Y, Luo Y, Gao Y, He L.
europepmc   +2 more sources

Distinct Profiles of Specialized Pro-Resolving Lipid Mediators and Corresponding Receptor Gene Expression In Periodontal Inflammation [PDF]

, 2020
Polyunsaturated fatty acid-derived specialized pro-resolving lipid mediators (SPMs) play an important role in modulating inflammation. The aim of the study was to compare profiles of SPMs, SPM related lipid mediators and SPM receptor gene expression in ...
Zhu, Lisha, Van Dyke, Thomas E, Bokka, Nishantha R, Maddipati, Krishna Rao, Ayilavarapu, Srinivas, Chen, Wanqi, Lee, Chun-Teh, Ferguson, Brittney, Angelov, Nikola, Weltman, Robin, Zheng, W Jim   +10 more
core   +1 more source

Specialized pro-resolving mediators as potential regulators of inflammatory macrophage responses in COVID-19

, 2021
The recent outbreak of SARS-CoV2 has emerged as one of the biggest pandemics of our century, with outrageous health, social and economic consequences globally.
Balta, Maria, Papathanasiou, Evangelos, Christopoulos, Panagiotis   +2 more
core   +1 more source

The role of specialized pro-resolving mediators in maternal-fetal health [PDF]

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2017
Infants developing in a pro-inflammatory intrauterine environment have a significant risk for severe complications after birth. It has been shown that omega-3 fatty acids reduce inflammation, and also reduce early preterm births and decrease risk of infant admission to the neonatal intensive care unit.
E, Elliott, C K, Hanson, A L, Anderson-Berry, T M, Nordgren   +3 more
openaire   +2 more sources