Specialized Pro-Resolving Lipid Mediators in Neonatal Cardiovascular Physiology and Diseases [PDF]
Antioxidants, 2021 Cardiovascular disease remains a leading cause of mortality worldwide. Unresolved inflammation plays a critical role in cardiovascular diseases development.
Andrea Gila-Diaz +3 more
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Specialized Pro-Resolving Lipid Mediators: Endogenous Roles and Pharmacological Activities in Infections [PDF]
Molecules, 2023 During an infection, inflammation mobilizes immune cells to eliminate the pathogen and protect the host. However, inflammation can be detrimental when exacerbated and/or chronic.
Fernanda S. Rasquel-Oliveira +5 more
doaj +4 more sources
Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far? [PDF]
Frontiers in Pharmacology, 2022 Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic acid 12- and 15-lipoxygenating paralogues (15-LO1, ALOX15; 15 ...
Nils Helge Schebb +22 more
doaj +5 more sources
Inflammation resolution-based treatment of atherosclerosis using biomimetic nanocarriers loaded with specialized pro-resolving lipid mediators [PDF]
Materials Today BioRecent studies have shown that chronic inflammation in atherosclerotic (ATH) lesions is due to an inability to resolve the inflammatory response. We evaluated the therapeutic potential of specialized pro-resolving mediators (SPMs) incorporated into ...
Maria Anghelache +9 more
doaj +5 more sources
Specialized Pro-Resolving Lipid Mediators in Pulmonary Diseases: Molecular and Therapeutic Implications [PDF]
MoleculesInflammatory lung diseases (ILDs) represent a global public health crisis characterized by escalating prevalence, significant morbidity, and substantial mortality.
Ángel Ortega +11 more
doaj +3 more sources
The Role of Specialized Pro-Resolving Lipid Mediators in Inflammation-Induced Carcinogenesis [PDF]
International Journal of Molecular Sciences, 2023 Cancer is a process involving cell mutation, increased proliferation, invasion, and metastasis. Over the years, this condition has represented one of the most concerning health problems worldwide due to its significant morbidity and mortality. At present,
Lissé Angarita Dávila +2 more
exaly +3 more sources
Current experimental methods to investigate the impact of specialized pro-resolving lipid mediators on Sjögren’s syndrome [PDF]
Frontiers in Immunology, 2023 Sjögren’s syndrome is a chronic inflammatory autoimmune disease characterized by diminished secretory function of the exocrine glands. Although extensive investigation has been done to understand Sjögren’s syndrome, the causes of the disease are as yet ...
Harim T. dos Santos +11 more
doaj +3 more sources
Role of specialized pro-resolving lipid mediators in pulmonary inflammation diseases: mechanisms and development [PDF]
Respiratory Research, 2021 Inflammation is an essential mechanism of various diseases. The development and resolution of inflammation are complex immune-modulation processes which induce the involvement of various types of immune cells.
Ailin Yang +3 more
doaj +3 more sources
Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy? [PDF]
International Journal of Molecular Sciences, 2021 Chronic pain (CP) is a severe clinical entity with devastating physical and emotional consequences for patients, which can occur in a myriad of diseases. Often, conventional treatment approaches appear to be insufficient for its management.
Alexander Manzano +2 more
exaly +3 more sources
Specialized Pro-resolving Lipid Mediators and Glial Cells: Emerging Candidates for Brain Homeostasis and Repair [PDF]
Frontiers in Cellular Neuroscience, 2021 Astrocytes and oligodendrocytes are known to play critical roles in the central nervous system development, homeostasis and response to injury. In addition to their well-defined functions in synaptic signaling, blood-brain barrier control and myelination,
Marta Tiberi +2 more
doaj +3 more sources