Sex differences in specialized pro-resolving lipid mediators and their receptors in abdominal aortic aneurysms [PDF]
JVS - Vascular Science, 2023 Objective: In this study, we tested the hypothesis that endogenous expression of specialized pro-resolving lipid mediators (SPMs) that facilitate the resolution of inflammation, specifically Resolvin D1and -D2, as well as Maresin1 (MaR1), can impact ...
Amanda C. Filiberto, MD +11 more
doaj +4 more sources
Alzheimer's Disease and Specialized Pro-Resolving Lipid Mediators: Do MaR1, RvD1, and NPD1 Show Promise for Prevention and Treatment? [PDF]
Int J Mol Sci, 2020 Alzheimer’s disease (AD) is a common neurodegenerative disease and a major contributor to progressive cognitive impairment in an aging society. As the pathophysiology of AD involves chronic neuroinflammation, the resolution of inflammation and the group ...
Miyazawa K +6 more
europepmc +3 more sources
Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis. [PDF]
Front Pharmacol, 2019 Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease.
Recchiuti A, Mattoscio D, Isopi E.
europepmc +4 more sources
Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial) [PDF]
Journal of Surgical Research, 2019 Background: N-3 polyunsaturated fatty acid (PUFA) supplementation has been associated with reduced mortality and inflammation in patients with cardiovascular disease.
Michael S. Conte +2 more
exaly +3 more sources
Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction [PDF]
EBioMedicine, 2019 Background Termination of acute inflammation is an active process orchestrated by lipid mediators (LM) derived from polyunsaturated fatty acids, referred to as specialized pro-resolving mediators (SPM).
Trond Vidar Hansen +2 more
exaly +3 more sources
Roles of Specialized Pro-Resolving Lipid Mediators in Autophagy and Inflammation [PDF]
International Journal of Molecular Sciences, 2020 Autophagy is a catabolic pathway that accounts for degradation and recycling of cellular components to extend cell survival under stress conditions. In addition to this prominent role, recent evidence indicates that autophagy is crucially involved in the
Mario Romano +2 more
exaly +5 more sources
Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin interventionResearch in context [PDF]
EBioMedicine, 2023 Summary: Background: Persons with HIV (PWH) have an increased risk of cardiovascular disease (CVD) compared to HIV-seronegative individuals (SN). Inflammation contributes to this risk but the role of lipid mediators, with central roles in inflammation ...
Jesmond Dalli +10 more
doaj +2 more sources
Specialized Pro-Resolving Lipid Mediators: New Therapeutic Approaches for Vascular Remodeling. [PDF]
Int J Mol Sci, 2022 Vascular remodeling is a typical feature of vascular diseases, such as atherosclerosis, aneurysms or restenosis. Excessive inflammation is a key mechanism underlying vascular remodeling via the modulation of vascular fibrosis, phenotype and function ...
Díaz Del Campo LS +4 more
europepmc +2 more sources
Specialized Pro-Resolving Lipid Mediators Regulate Ozone-Induced Pulmonary and Systemic Inflammation [PDF]
Toxicological Sciences, 2018 Nichole Reisdorph +2 more
exaly +3 more sources
Specialized pro-resolving lipid mediators regulate inflammatory macrophages: A paradigm shift from antibiotics to immunotherapy for mitigating COVID-19 pandemic. [PDF]
Front Mol Biosci, 2023 The most severe clinical manifestations of the horrifying COVID-19 disease, that claimed millions of lives during the pandemic time, were Acute respiratory distress syndrome (ARDS), Coagulopathies, septic shock leading eventually to death.
Kumar V +10 more
europepmc +2 more sources