Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction [PDF]
Haematologica, 2020 Chronic inflammation is a key pathological hallmark of multiple sclerosis (MS) and suggests that resolution of inflammation, orchestrated by specialized pro-resolving lipid mediators (LM), is impaired.
Gijs Kooij* +19 more
doaj +5 more sources
PCOS: A Chronic Disease That Fails to Produce Adequately Specialized Pro-Resolving Lipid Mediators (SPMs) [PDF]
Biomedicines, 2022 Introduction: Polycystic ovary syndrome (PCOS) is an endocrinological disorder that affects 5–15% of women of their reproductive age and is a frequent cause of infertility. Major symptoms include hyperandrogenism, ovulatory dysfunction, and often obesity
Pedro-Antonio Regidor +6 more
doaj +4 more sources
Distinct Profiles of Specialized Pro-resolving Lipid Mediators and Corresponding Receptor Gene Expression in Periodontal Inflammation [PDF]
Frontiers in Immunology, 2020 Polyunsaturated fatty acid-derived specialized pro-resolving lipid mediators (SPMs) play an important role in modulating inflammation. The aim of the study was to compare profiles of SPMs, SPM related lipid mediators and SPM receptor gene expression in ...
Brittney Ferguson +11 more
doaj +5 more sources
Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications [PDF]
Molecules, 2022 Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and ...
Mariarosaria Valente +4 more
doaj +4 more sources
Inflammation resolution and specialized pro-resolving lipid mediators in chronic rhinosinusitis. [PDF]
Expert Rev Clin Immunol, 2023 Introduction In chronic rhinosinusitis (CRS), a complex pathophysiology results from varied pro-inflammatory stimuli but is consistently characterized by classic cellular, molecular, and microbial alterations.
Robinson PZ, Frank DN, Ramakrishnan VR.
europepmc +3 more sources
Specialized pro-resolving lipid mediators in endodontics: a narrative review [PDF]
BMC Oral Health, 2021 Endodontics is the branch of dentistry concerned with the morphology, physiology, and pathology of the human dental pulp and periradicular tissues. Human dental pulp is a highly dynamic tissue equipped with a network of resident immunocompetent cells ...
Davy Aubeux +6 more
doaj +3 more sources
An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques [PDF]
Nature Communications, 2016 Atherosclerosis progression is linked to inflammatory processes in the blood vessel wall. Here, the authors show that, with the progression of atherosclerosis, the resolution of inflammation is impaired as the result of an imbalance between specialized ...
Gabrielle Fredman +11 more
doaj +3 more sources
Development and Validation of Methodologies for the Identification of Specialized Pro-Resolving Lipid Mediators and Classic Eicosanoids in Biological Matrices [PDF]
Journal of the American Society for Mass SpectrometryLipid mediators, which include specialized pro-resolving mediators and classic eicosanoids, are pivotal in both initiating and resolving inflammation.
Jesmond Dalli
exaly +3 more sources
Specialized Pro-Resolving Lipid Mediators and Dietary Omega-3/6 Fatty Acids in Selected Inflammatory Skin Diseases: A Systematic Review [PDF]
AntioxidantsSpecialized pro-resolving mediators (SPMs), including lipoxins, resolvins, protectins, and maresins, actively terminate inflammation and restore tissue homeostasis.
Angelika Biełach-Bazyluk +3 more
doaj +3 more sources
Roles of Specialized Pro-Resolving Lipid Mediators in Cerebral Ischemia Reperfusion Injury [PDF]
Frontiers in Neurology, 2018 Ischemic stroke contributes to ~80% of all stroke cases. Recanalization with thrombolysis or endovascular thrombectomy are currently critical therapeutic strategies for rebuilding the blood supply following ischemic stroke.
Ping Yin +5 more
doaj +3 more sources