Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction [PDF]
Haematologica, 2020 Chronic inflammation is a key pathological hallmark of multiple sclerosis (MS) and suggests that resolution of inflammation, orchestrated by specialized pro-resolving lipid mediators (LM), is impaired.
Gijs Kooij* +19 more
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The Role of Specialized Pro-Resolving Mediators in Cystic Fibrosis Airways Disease [PDF]
Frontiers in Pharmacology, 2020 Cystic Fibrosis (CF) is a recessive genetic disease due to mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene encoding the CFTR chloride channel. The ion transport abnormalities related to CFTR mutation generate a dehydrated
Maelle Briottet +2 more
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Roles of Specialized Pro-Resolving Lipid Mediators in Cerebral Ischemia Reperfusion Injury
Frontiers in Neurology, 2018 Ischemic stroke contributes to ~80% of all stroke cases. Recanalization with thrombolysis or endovascular thrombectomy are currently critical therapeutic strategies for rebuilding the blood supply following ischemic stroke.
Ping Yin +5 more
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Specialized pro-resolving mediators in respiratory diseases. [PDF]
Curr Opin Clin Nutr Metab Care, 2022 Purpose of review Persistent unresolved inflammation results in a number of pathologic respiratory diseases including asthma, cystic fibrosis, acute respiratory distress syndrome (ARDS) and coronavirus disease 2019 (COVID-19)-associated ARDS.
Cagnina RE +3 more
europepmc +3 more sources
Specialized Pro-Resolving Mediators at the Ocular Surface: Biosynthesis, Mechanisms, and Therapeutic Potential. [PDF]
Biology (Basel)Specialized pro-resolving mediators (SPMs) are endogenous lipid mediators that actively orchestrate the resolution of inflammation rather than relying solely on broad suppression of inflammatory signaling.
Gandhi S, Shokravi A, Buhrow S, Balas M.
europepmc +2 more sources
Progress of specialized pro-resolving mediators in diabetic kidney disease [PDF]
Jichu yixue yu linchuang, 2023 Specialized pro-resolving mediators (SPMs) can promote the regression of chronic inflammatory response in diabetic kidney disease (DKD), inhibit renal fibrosis and protect renal function by inhibiting renal intrinsic cell inflammatory response ...
LIU Chong, LIU Yingying, GUO Zhaoan
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Is there a role for specialized pro-resolving mediators in pulmonary fibrosis? [PDF]
Pharmacol Ther, 2023 Pulmonary fibrotic diseases are characterized by proliferation of lung fibroblasts and myofibroblasts and excessive deposition of extracellular matrix proteins. Depending on the specific form of lung fibrosis, there can be progressive scarring of the lung, leading in some cases to respiratory failure and/or death.
Thatcher TH +3 more
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Specialized pro-resolving mediators: do they circulate in plasma?1 [PDF]
Journal of Lipid Research, 2015 This issue of the Journal of Lipid Research reports a patient-oriented study by workers at the University of Pennsylvania (Penn group) (1) using n-3 PUFA ester supplementation in attempts to detect the appearance of oxidized DHA and EPA in plasma and urine. Fish oil and purified n-3 PUFA supplementations have certainly emerged on the conscious level of
Robert C. Murphy
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Frontiers in Immunology, 2023 Sjögren’s syndrome is a chronic inflammatory autoimmune disease characterized by diminished secretory function of the exocrine glands. Although extensive investigation has been done to understand Sjögren’s syndrome, the causes of the disease are as yet ...
Harim T. dos Santos +11 more
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Specialized pro-resolving lipid mediators and resolution of viral diseases
Prostaglandins & Other Lipid Mediators, 2023 The COVID-19 pandemics has made sparkly evident the importance of acute inflammation and its timely resolution to protect humans from pathogenic viruses while sparing them from collateral damages due to an uncontrolled immune response. It is clear now that resolution of inflammation is an active process regulated by endogenous specialized proresolving ...
Ferri, Giulia +3 more
openaire +3 more sources