Results 21 to 30 of about 2,369,325 (253)

Pharmacological effects of specialized pro-resolving mediators in sepsis-induced organ dysfunction: a narrative review [PDF]

Frontiers in Immunology
Sepsis is a life-threatening syndrome of organ dysfunction, characterized by uncontrolled inflammatory response and immune dysregulation, often leading to multiple organ failure and even death.
Shujun Sun, Shujun Sun, Shujun Sun, Shujun Sun, Dong Yang, Dong Yang, Dong Yang, Jing Lv, Jing Lv, Jing Lv, Haifa Xia, Haifa Xia, Haifa Xia, Zhangyan Mao, Zhangyan Mao, Zhangyan Mao, Zhangyan Mao, Xiangdong Chen, Xiangdong Chen, Xiangdong Chen, Yafen Gao, Yafen Gao, Yafen Gao   +22 more
doaj   +4 more sources

Altered tissue specialized pro-resolving mediators in chronic rhinosinusitis. [PDF]

Prostaglandins Leukot Essent Fatty Acids, 2021
Current literature implicates arachidonic acid-derived leukotrienes and prostaglandins in the pathogenesis of chronic rhinosinusitis. However, other omega-3 and omega-6 derived lipid mediators, such as specialized pro-resolving mediators (SPMs), may also
Vickery TW, Armstrong M, Kofonow JM, Robertson CE, Kroehl ME, Reisdorph NA, Ramakrishnan VR, Frank DN.   +7 more
europepmc   +5 more sources

Targeted Delivery of Specialized Pro-Resolving Mediators (SPMs) for Improved Treatments of Inflammatory Diseases and Cancer [PDF]

Pharmaceutics
Acute and chronic inflammation underlies the pathogenesis of numerous diseases, including autoimmune disorders, atherosclerosis, infections, and cancer.
Adeola Aminu, Zhenjia Wang
doaj   +2 more sources

Specialized pro-resolving lipid mediators in endodontics: a narrative review [PDF]

BMC Oral Health, 2021
Endodontics is the branch of dentistry concerned with the morphology, physiology, and pathology of the human dental pulp and periradicular tissues. Human dental pulp is a highly dynamic tissue equipped with a network of resident immunocompetent cells ...
Davy Aubeux, Ove A. Peters, Sepanta Hosseinpour, Solène Tessier, Valérie Geoffroy, Fabienne Pérez, Alexis Gaudin   +6 more
doaj   +7 more sources

Specialized Pro-Resolving Mediators Reduce Scarring After Cleft Lip Repair [PDF]

Frontiers in Immunology, 2022
ObjectiveResidual scarring after cleft lip repair surgery remains a challenge for both surgeons and patients and novel therapeutics are critically needed. The objective of this preclinical experimental study was to evaluate the impact of the methyl-ester
Evangelos Papathanasiou, Evangelos Papathanasiou, Andrew R. Scott, Carroll Ann Trotman, Corinna Beale, Lori Lyn Price, Lori Lyn Price, Gordon S. Huggins, Yang Zhang, Irene Georgakoudi, Thomas E. Van Dyke, Thomas E. Van Dyke   +11 more
doaj   +2 more sources

PCOS: A Chronic Disease That Fails to Produce Adequately Specialized Pro-Resolving Lipid Mediators (SPMs)

Biomedicines, 2022
Introduction: Polycystic ovary syndrome (PCOS) is an endocrinological disorder that affects 5–15% of women of their reproductive age and is a frequent cause of infertility. Major symptoms include hyperandrogenism, ovulatory dysfunction, and often obesity
Pedro-Antonio Regidor, Xavier de la Rosa, Anna Müller, Manuela Mayr, Fernando Gonzalez Santos, Rafael Gracia Banzo, Jose Miguel Rizo   +6 more
doaj   +2 more sources

Advances in the role of specialized pro-resolving mediators in periodontitis [PDF]

Frontiers in Immunology
Periodontitis is a chronic inflammatory disease driven by dysregulated host–microbial interactions and failure of endogenous inflammation resolution, leading to progressive destruction of periodontal tissues.
Huiting Hu, Hongxing Chu, Zhenzhen Wu, Zekun Gan, Yong Yang   +4 more
doaj   +2 more sources

Role of Specialized Pro-resolving Mediators in Reducing Neuroinflammation in Neurodegenerative Disorders [PDF]

Frontiers in Aging Neuroscience, 2022
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are neurodegenerative disorders that affect millions of individuals worldwide. As incidence of these conditions increases with age, there will undoubtedly be an increased prevalence of cases in the ...
Jana Ponce, Arzu Ulu, Corrine Hanson, Erin Cameron-Smith, John Bertoni, Jenna Wuebker, Alfred Fisher, Ka-Chun Siu, Vivien Marmelat, Jiri Adamec, Danish Bhatti   +10 more
doaj   +2 more sources

Specialized pro-resolving mediators in neutrophil apoptosis regulation: unlocking novel therapeutic potential in kidney diseases [PDF]

Frontiers in Immunology
Kidney diseases represent a diverse group of disorders with pathogenic mechanisms involving multiple pathological processes, including inflammation, immunity, and cell death.
Yi Kang, Yi Kang, Yi Kang, Qian Jin, Mengqi Zhou, Huijuan Zheng, Huijuan Zheng, Danwen Li, Danwen Li, Danwen Li, Xuezhe Wang, Xuezhe Wang, Xuezhe Wang, Jingwei Zhou, Jingwei Zhou, Yaoxian Wang, Jie Lv   +16 more
doaj   +2 more sources

Inflammation resolution and specialized pro-resolving lipid mediators in chronic rhinosinusitis

Expert Review of Clinical Immunology, 2023
Introduction: In chronic rhinosinusitis (CRS), a complex pathophysiology results from varied pro-inflammatory stimuli but is consistently characterized by classic cellular, molecular, and microbial alterations.
Peyton Z. Robinson, Daniel N. Frank, Ramakrishnan, Vijay R., Vijay R. Ramakrishnan, Frank, Daniel N., Robinson, Peyton Z.   +5 more
core   +3 more sources