Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications [PDF]
Molecules, 2022 Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and ...
Mariarosaria Valente +4 more
doaj +6 more sources
Role of Specialized Pro-Resolving Mediators in Neuropathic Pain [PDF]
Frontiers in Pharmacology, 2021 Inflammation and neuroinflammation are critical mechanisms in the generation of neuropathic pain that is experienced in several chronic diseases. The aberrant inflammation that triggers this pathophysiologic process can be tracked down to an exacerbated ...
Alessandro Leuti +6 more
doaj +10 more sources
Biology and Total Synthesis of n-3 Docosapentaenoic Acid-Derived Specialized Pro-Resolving Mediators [PDF]
MoleculesResearch over the last 25 years related to structural elucidations and biological investigations of the specialized pro-resolving mediators has spurred great interest in targeting these endogenous products in total synthesis. These lipid mediators govern
Amalie Føreid Reinertsen +2 more
doaj +5 more sources
The Use of Specialized Pro-Resolving Mediators in Biomaterial-Based Immunomodulation [PDF]
Journal of Functional Biomaterials, 2023 The implantation of a biomaterial will lead to the immediate onset of an acute inflammatory response, which is of key importance in shaping the quality of the repair process.
Ana Beatriz Sousa, Judite N. Barbosa
doaj +5 more sources
The Role of Sphingolipids and Specialized Pro-Resolving Mediators in Alzheimer’s Disease [PDF]
Frontiers in Immunology, 2021 Alzheimer’s disease (AD) is the leading cause of dementia worldwide giving rise to devastating forms of cognitive decline, which impacts patients’ lives and that of their proxies.
Nienke M. de Wit +4 more
doaj +8 more sources
Specialized Pro-Resolving Mediators and the Lymphatic System [PDF]
International Journal of Molecular Sciences, 2021 Diminished lymphatic function and abnormal morphology are common in chronic inflammatory diseases. Recent studies are investigating whether it is possible to target chronic inflammation by promoting resolution of inflammation, in order to enhance ...
Iben Lundgaard, Emma Börgeson
exaly +8 more sources
Specialized Pro-Resolving Lipid Mediators in Neonatal Cardiovascular Physiology and Diseases [PDF]
Antioxidants, 2021 Cardiovascular disease remains a leading cause of mortality worldwide. Unresolved inflammation plays a critical role in cardiovascular diseases development.
Andrea Gila-Diaz +3 more
doaj +7 more sources
Immunosuppression in Sepsis: Biomarkers and Specialized Pro-Resolving Mediators [PDF]
BiomedicinesSevere infection can lead to sepsis. In sepsis, the host mounts an inappropriately large inflammatory response in an attempt to clear the invading pathogen. This sustained high level of inflammation may cause tissue injury and organ failure.
Cristina M. Padovani, Kingsley Yin
doaj +4 more sources
Pro-Resolving Inflammatory Effects of a Marine Oil Enriched in Specialized Pro-Resolving Mediators (SPMs) Supplement and Its Implication in Patients with Post-COVID Syndrome (PCS) [PDF]
BiomedicinesObjectives: This study aimed to evaluate the eicosanoid and pro-resolutive parameters in patients with Post-COVID Syndrome (PCS) during a 12-week supplementation with a marine oil enriched in specialized pro-resolving mediators (SPMs).
Asun Gracia Aznar +7 more
doaj +4 more sources
Specialized pro-resolving mediators as modulators of immune responses [PDF]
Seminars in Immunology, 2022 Specialized pro-resolving mediators (SPMs) are endogenous small molecules produced mainly from dietary omega-3 polyunsaturated fatty acids by both structural cells and cells of the active and innate immune systems. Specialized pro-resolving mediators have been shown to both limit acute inflammation and promote resolution and return to homeostasis ...
Peter Jackson +2 more
exaly +4 more sources