Cyclopentenone-containing oxidized phospholipids and their isoprostanes as pro-resolving mediators of inflammation. [PDF]
, 2017 Inflammation represents a powerful innate immune response that defends tissue homeostasis. However, the appropriate termination of inflammatory processes is essential to prevent the development of chronic inflammatory disorders.
Friedli, Olivier +3 more
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Utility of the Specialized Pro-Resolving Mediators as Diagnostic and Prognostic Biomarkers in Disease. [PDF]
Biomolecules, 2022 A precision medicine approach is widely acknowledged to yield more effective therapeutic strategies in the treatment of patients with chronic inflammatory conditions than the prescriptive paradigm currently utilized in the management and treatment of these patients.
Dalli J, Gomez EA, Jouvene CC.
europepmc +6 more sources
Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention [PDF]
, 2023 BACKGROUND: Persons with HIV (PWH) have an increased risk of cardiovascular disease (CVD) compared to HIV-seronegative individuals (SN). Inflammation contributes to this risk but the role of lipid mediators, with central roles in inflammation, in HIV ...
Hunt, Peter W +10 more
core +1 more source
The regulatory effect of specialized pro-resolving mediators on immune cells
Biomedicine & Pharmacotherapy, 2022 Appropriate inflammation is an effective weapon for the body to fight against harmful stimuli, while excessive or prolonged inflammatory reactions could lead to tissue destruction, fibrosis, and even organ failure. The timely termination of inflammatory response is of great significance for maintaining the homeostasis of the body.
Guangtao, Pan +3 more
openaire +2 more sources
CCL2 Inhibition of Pro-Resolving Mediators Potentiates Neuroinflammation in Astrocytes [PDF]
, 2022 The chemokine CCL2 participates in multiple neuroinflammatory processes, mainly through the recruitment of glial cells. However, CCL2 has also been proven to exert different types of actions on these cells, including the modification of their response to
García-Bueno, Borja +16 more
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Specialized pro-resolving lipid mediators in the inflammatory response: An update [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010 A new genus of specialized pro-resolving mediators (SPM) which include several families of distinct local mediators (lipoxins, resolvins, protectins, and maresins) are actively involved in the clearance and regulation of inflammatory exudates to permit restoration of tissue homeostasis.
Gerard, Bannenberg, Charles N, Serhan
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Specialized pro‐resolving mediators: biosynthesis and biological role in bacterial infections [PDF]
The FEBS Journal, 2021 Acute inflammation caused by bacterial infections is an essential biological defence mechanism of the host in order to neutralize and clear the invaders and to return to homeostasis. Despite its protective function, inflammation may become persistent and uncontrolled, resulting in chronic diseases and tissue destruction as consequence of the unresolved
Paul M. Jordan, Oliver Werz
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In vivo availability of pro-resolving lipid mediators in oxazolone induced dermal inflammation in the mouse [PDF]
, 2015 The activation and infiltration of polymorphonuclear neutrophils (PMN) are critical key steps in inflammation. PMN-mediated inflammation is limited by anti-inflammatory and pro-resolving mechanisms, including specialized pro-resolving lipid mediators ...
Geisslinger, Gerd +20 more
core +2 more sources
Specialized pro-resolving mediators: endogenous regulators of infection and inflammation
Nature Reviews Immunology, 2015 Specialized pro-resolving mediators (SPMs) are enzymatically derived from essential fatty acids and have important roles in orchestrating the resolution of tissue inflammation - that is, catabasis. Host responses to tissue infection elicit acute inflammation in an attempt to control invading pathogens. SPMs are lipid mediators that are part of a larger
Basil, Maria C., Levy, Bruce D.
openaire +3 more sources
, 2018 Objective: Acute respiratory distress syndrome (ARDS) is an acute and lethal clinical syndrome that is characterized by the injury of alveolar epithelium, which impairs active fluid transport in the lung, and impedes the reabsorption of edema fluid from ...
Song-Fan Yan +3 more
core +1 more source