Results 71 to 80 of about 2,369,325 (253)

Therapeutic Effects of Specialized Pro-Resolving Lipids Mediators on Cardiac Fibrosis via NRF2 Activation

, 2020
Heart disease is the number one mortality disease in the world. In particular, cardiac fibrosis is considered as a major factor causing myocardial infarction and heart failure. In particular, oxidative stress is a major cause of heart fibrosis.
Gyeoung Jin Kang, Eun Ji Kim, Chang Hoon Lee   +2 more
core   +1 more source

Pro-Resolving Mediators in Rotator Cuff Disease: How Is the Bursa Involved? [PDF]

, 2023
So far, tendon regeneration has mainly been analyzed independent from its adjacent tissues. However, the subacromial bursa in particular appears to influence the local inflammatory milieu in the shoulder.
Klatte-Schulz, Franka, Philipp Moroder, Thiele, Kathi, Sawitzki, Birgit, Klöckner, Pascal, Kathi Thiele, Jasmin Al-Michref, Bormann, Nicole, Britt Wildemann, Franka Klatte-Schulz, Duda, Georg N., Seifert, Martina, Pascal Klöckner, Al-Michref, Jasmin, Nicole Bormann, Georg N. Duda, Aysha Bonell, Birgit Sawitzki, Hoang Le Nguyen, Bonell, Aysha, Nguyen, Hoang Le, Martina Seifert, Wildemann, Britt, Moroder, Philipp   +23 more
core   +1 more source

The role of specialized pro-resolving mediators in skin inflammation

Pifu-xingbing zhenliaoxue zazhi
Specialized pro-resolving mediators (SPMs) are endogenous lipid molecules that are biosynthesized from ω-3/ω-6 polyunsaturated fatty acids via key enzymes such as lipoxygenases and cyclooxygenases.
WANG Yuying, LIN Simin, WANG Xiaoying, WEI Yun, WANG Fuming, XIAO Yue, HUANG Hu, WANG Jing   +7 more
doaj   +1 more source

Specialized pro-resolving mediators in vascular inflammation and atherosclerotic cardiovascular disease. [PDF]

Nat Rev Cardiol
Timely resolution of the acute inflammatory response (or inflammation resolution) is an active, highly coordinated process that is essential to optimal health. Inflammation resolution is regulated by specific endogenous signalling molecules that function as 'stop signals' to terminate the inflammatory response when it is no longer needed; to actively ...
Fredman G, Serhan CN.
europepmc   +3 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Randomized, double-blind, placebo-controlled study to evaluate the effect of treatment with an SPMs-enriched oil on chronic pain and inflammation, functionality, and quality of life in patients with symptomatic knee osteoarthritis: GAUDI study

Journal of Translational Medicine, 2023
Background Specialized pro-resolving mediators (SPMs), including 18-HEPE, 17-HDHA, and 14-HDHA are recognized as potentially therapeutic in inflammatory diseases because SPMs regulate the inflammation process, which leads to, for example; swelling and ...
Ingrid Möller, Gil Rodas, Jose María Villalón, Jose A. Rodas, Francisco Angulo, Nina Martínez, Josep Vergés   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Pro-Resolving Mediator Annexin A1 Regulates Intracellular Ca2+ and Mucin Secretion in Cultured Goblet Cells Suggesting a New Use in Inflammatory Conjunctival Diseases

Frontiers in Immunology, 2021
The amount of mucin secreted by conjunctival goblet cells is regulated to ensure the optimal level for protection of the ocular surface. Under physiological conditions lipid specialized pro-resolving mediators (SPM) are essential for maintaining tissue ...
Anne V. Lyngstadaas, Anne V. Lyngstadaas, Anne V. Lyngstadaas, Markus V. Olsen, Markus V. Olsen, Markus V. Olsen, Jeffrey A. Bair, Robin R. Hodges, Tor P. Utheim, Tor P. Utheim, Tor P. Utheim, Charles N. Serhan, Darlene A. Dartt   +12 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Synthesis, Structural Confirmation, and Biosynthesis of 22-OH-PD1_{n-3 DPA}

Molecules, 2019
PD1n-3 DPA belongs to the protectin family of specialized pro-resolving lipid mediators. The protectins are endogenously formed mediators that display potent anti-inflammatory properties and pro-resolving bioactivities and have attracted interest in drug
Jannicke Irina Nesman, Karoline Gangestad Primdahl, Jørn Eivind Tungen, Fransesco Palmas, Jesmond Dalli, Trond Vidar Hansen   +5 more
doaj   +1 more source