Results 111 to 120 of about 4,157,285 (290)

DNA Barcoding Supports “Color-Pattern’’-Based Species of Stictochironomus from China (Diptera: Chironomidae)

Insects
The genus Stictochironomus (Diptera: Chironomidae) has an almost worldwide distribution, with more than 30 species. However, species delimitation and identification based on the markings on the wings and legs are controversial and uncertain.
Chao Song, Guanyu Chen, Le Wang, Teng Lei, Xin Qi   +4 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Species delimitation according to the literature, literature delimitation checked by patristic distances, ABGD species delimitations and GMYC species delimitations.

, 2014
(1): delimitation invalidation due to improbable inter-species distances; (2): delimitation invalidation due to overlapping of intra- and inter-species distances; n.d.: no genetic type defined in the literature; n.a.: genetic type not included in the ...
Aurore André (614735), Colomban de Vargas (103556), Christophe J. Douady (200011), Frédéric Quillévéré (200008), Thibault de Garidel-Thoron (200015), Yurika Ujiié (167151), Raphaël Morard (200006), Gilles Escarguel (200019)   +7 more
core   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

DNA barcoding for community ecology--how to tackle a hyperdiverse, mostly undescribed Melanesian fauna. [PDF]

, 2012
Trigonopterus weevils are widely distributed throughout Melanesia and hyperdiverse in New Guinea. They are a dominant feature in natural forests, with narrow altitudinal zonation.
Riedel, Alexander, Balke, Michael, Sagata Katayo, Suriani Surbakti (188485), Suriani Surbakti, Tänzler Rene, Riedel Alexander, Sagata, Katayo, Alexander Riedel, Alexander Riedel (188493), Tänzler, Rene, Katayo Sagata, Surbakti, Suriani, Michael Balke, Surbakti Suriani, Balke Michael, Katayo Sagata (188481), Rene Tänzler, Rene Tänzler (188478), Michael Balke (188490)   +19 more
core   +2 more sources

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

Advanced Science, EarlyView.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo, Rohit Verma, Sydney C. Nagy, Mausam Kalita, Samuel Aubert, Josué Ballesteros‐Álvarez, Pedro Machado Almeida, Hannes Vogel, Israt S. Alam, Michael Lim, Michelle L. James   +10 more
wiley   +1 more source

Delimitation of the widely distributed Palearctic Stenodema species (Hemiptera, Heteroptera, Miridae): insights from molecular and morphological data [PDF]

ZooKeys
Species delimitation presents a significant challenge in biology, particularly in systematics. Here, an integrative approach is employed to assess the species boundaries of widely distributed Palearctic Stenodema species.
Anna A. Namyatova, Polina A. Dzhelali, Fedor V. Konstantinov   +2 more
doaj   +3 more sources

DNA-based species delimitation in algae

, 2014
Given the problems of species delimitation in algae using morphology or sexual compatibility, molecular data are becoming the standard for delimiting species and testing their traditional boundaries.
Zuccarello, Giuseppe C, Olivier De Clerck (186236), Pieter Vanormelingen (221944), Lopez-Bautista, Juan M, De Clerck, Olivier, Giuseppe C. Zuccarello (434010), Frederik Leliaert (186222), Verbruggen, Heroen, Vanormelingen, Pieter, Juan M. López-Bautista (435257), Frederique Steen (572886), Leliaert, Frédérik, Heroen Verbruggen (148046), Steen, Frederique   +13 more
core   +1 more source

Unguided Species Delimitation Using DNA Sequence Data from Multiple Loci [PDF]

, 2014
A method was developed for simultaneous Bayesian inference of species delimitation and species phylogeny using the multispecies coalescent model. The method eliminates the need for a user-specified guide tree in species delimitation and incorporates ...
Rannala, B, Yang, Ziheng, Yang, Z, Rannala, Bruce   +3 more
core   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source