Results 91 to 100 of about 1,000,230 (261)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Impacts of Climate Change on the Geographic Distribution of Dioscorea zingiberensis, a Traditional Medicinal Plant in China

Plants
D. zingiberensis C. H. Wright is a medicinally significant herbaceous vine endemic to China. Investigating the geographical distribution and migration routes of D.
Ting-Ting Zhang, Xin Jiang, Hao-Ran Yang, Yun Jia   +3 more
doaj   +1 more source

Forecasting Brassica napus production under climate change with a mechanistic species distribution model. [PDF]

Sci Rep, 2023
Borges CE, Von Dos Santos Veloso R, da Conceição CA, Mendes DS, Ramirez-Cabral NY, Shabani F, Shafapourtehrany M, Nery MC, da Silva RS.   +8 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Updated range map of an endangered salamander and congeneric competitor reveals different niche preferences

Ecology and Evolution
Estimating distributions for cryptic and highly range‐restricted species induces unique challenges for species distribution modeling. In particular, bioclimatic covariates that are typically used to model species ranges at regional and continental scales
Jo A. Werba, David A. W. Miller, Adrianne B. Brand, Evan H. Campbell Grant   +3 more
doaj   +1 more source

Predicting the Current and Future Distributions of Frankliniella occidentalis (Pergande) Based on the MaxEnt Species Distribution Model. [PDF]

Insects, 2023
Wang Z, Xu D, Liao W, Xu Y, Zhuo Z.
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Species Distribution Model for the Asian Tapir and Vegetation Characteristics of Batang Gadis National Park, North Sumatra, Indonesia. [PDF]

Trop Life Sci Res, 2023
Kuswanda W, Hutapea FJ, Saputra MH, Nopandry B.   +3 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Spatial distribution of Glossina morsitans (Diptera: Glossinidae) in Zambia: A vehicle-mounted sticky trap survey and Maxent species distribution model. [PDF]

PLoS Negl Trop Dis, 2023
Muyobela J, Pirk CWW, Yusuf AA, Sole CL.
europepmc   +1 more source