Results 71 to 80 of about 1,002,080 (260)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Wildlife Occupancy Estimation in Forests Using Occupancy Models [PDF]

Geo Data
Reliable spatial data on wildlife occurrence are essential for ecological monitoring and environmental assessment, yet detection uncertainty often limits their interpretability.
Jihoon Lee, Giyeong Jeong, Sunyong Sung, Yongwon Mo   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Predicting suitable habitats of parasitic desert species based on Biomod2 ensemble model: Cynomorium songaricum rupr and its host plants as an example

BMC Plant Biology
Background As a species of considerable medicinal, ecological, and economic significance, the protection of C. songaricum and its host plants is of paramount importance.
Lucun Yang, Huamei Jia, Qing Hua
doaj   +1 more source

Invasion Status, Mechanisms, and Future Distribution Prediction of Solidago canadensis in the Trade Port Region: A Case Study of Ningbo Port, China

Plants
Trade ports are the first places where alien species invade and the source of their spread to other areas. Controlling invasions in these regions can effectively reduce invasion pressure and disrupt the spread pathways of invasive species, thereby ...
Xu Luo, Sixiao Shen, Ke Liao, Saiqiang Li, Qinqin Pan, Jiahao Ma, Weiqiang Li, Xiaodong Yang   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Amphibians reveal unexpectedly large differences in potential climate change responses among ecologically similar habitat specialists

Ecological Indicators
Climate change is substantially impacting earth’s biodiversity, with a massive number of affected species that are difficult to study comprehensively.
Sky T. Button, Donald J. Brown, Jonah Piovia-Scott   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Did the climate changes cause the extinction of the Late Pleistocene gomphotheres in South America? [PDF]

Zoologia (Curitiba)
A global wave of megafauna extinctions occurred between 50,000 and 10,000 years ago, impacting numerous large continental mammals that are crucial to ecosystem dynamics.
Evelyn N.S. Cruz, Søren Faurby, Ricardo J. Sawaya   +2 more
doaj   +1 more source

Inferring the similarity of species distributions using Species’ Distribution Models

Ecography, 2013
A common problem in ecology is our need to reliably compare information on the distributions of distinct species. Since it is not always possible to directly compare the distributions of two species, numerous papers now seek to compare the predictions of Species’ Distribution Models (SDMs, estimates of the probability that two species are present ...
openaire   +2 more sources