Results 71 to 80 of about 1,000,230 (261)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Guiding conservation strategies for China’s Corybas species through species distribution modeling

open access: yesGlobal Ecology and Conservation
Corybas Salisb. is a widespread plant genus in the family Orchidaceae, known for its small, beautiful flowers. Most species in this genus are narrow endemics.
Li-Dan Tao   +5 more
doaj   +1 more source

The importance of climatic, topographic and edaphic variables in the distribution of yew species (Taxus baccata L.) and prioritization of areas for conservation and restoration in the north of Iran [PDF]

open access: yesمجله جنگل ایران, 2020
Taxus baccata is an indigenous and valuable species of Hyrcanian Forests. According to recent studies, the presence of this species in the areas where distribution is declining; therefore, preserving and restoring this valuable species is essential.
Jalil Alavi   +4 more
doaj  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Past legacies and future trajectories: climatic refugia, range shifts, and conservation gaps for the endangered Oglethorpe oak (Quercus oglethorpensis)

open access: yesFrontiers in Forests and Global Change
IntroductionThe endangered Quercus oglethorpensis is a narrowly distributed tree species endemic to the southeastern United States, persisting in fragmented, poorly drained hardwood forests.
Suresh C. Subedi   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Human activities and climate change are the main factors of amphibian extinction

open access: yesGlobal Ecology and Conservation
Human activities and climate change directly influencing species distribution and species richness leading to approximately 41 % of the ∼ 8009 Amphibian species being threatened with extinction.
Zhong Chen   +3 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Editorial: The potential impacts of climate change on the distribution of tree species

open access: yesFrontiers in Forests and Global Change, 2023
Yanlong Guo   +4 more
doaj   +1 more source

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