Results 81 to 90 of about 1,002,080 (260)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Guiding conservation strategies for China’s Corybas species through species distribution modeling
Global Ecology and ConservationCorybas Salisb. is a widespread plant genus in the family Orchidaceae, known for its small, beautiful flowers. Most species in this genus are narrow endemics.
Li-Dan Tao +5 more
doaj +1 more source
The importance of climatic, topographic and edaphic variables in the distribution of yew species (Taxus baccata L.) and prioritization of areas for conservation and restoration in the north of Iran [PDF]
مجله جنگل ایران, 2020 Taxus baccata is an indigenous and valuable species of Hyrcanian Forests. According to recent studies, the presence of this species in the areas where distribution is declining; therefore, preserving and restoring this valuable species is essential.
Jalil Alavi +4 more
doaj
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Human activities and climate change are the main factors of amphibian extinction
Global Ecology and ConservationHuman activities and climate change directly influencing species distribution and species richness leading to approximately 41 % of the ∼ 8009 Amphibian species being threatened with extinction.
Zhong Chen +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Editorial: The potential impacts of climate change on the distribution of tree species
Frontiers in Forests and Global Change, 2023 Yanlong Guo +4 more
doaj +1 more source