Results 81 to 90 of about 7,579,699 (309)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Sex Identification of Four Penguin Species Using Locus-Specific PCR

, 2013
Traditional methods for sex identification are not applicable to sexually monomorphic species, leading to difficulties in the management of their breeding programs.
Zhang, Xianfeng, Zhang, Peijun, Liu, Quansheng, Zhang, Junxin, Zhang, XF (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China., Han, Jiabo   +5 more
core   +1 more source

Utility of mitochondrial COI gene for identification of wild ungulate species of conservational importance from Pakistan

Mitochondrial DNA. Part B. Resources, 2020
Most of the ungulates of Pakistan are either threatened or endangered species and their solitary and inaccessible life style makes them difficult to study. Therefore, estimating biodiversity, monitoring illegal trades and detecting commercial food frauds
Asif Naseem, Sajida Batool, Fakhar- i- Abbas   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Invasive Species Definition Clarification and Guidance White Paper

, 2006
Paper discussing a "a non-regulatory policy interpretation of the term invasive species" through a positional defintion of what and what does not constittue an invasive species along with examples of impacts caused by invasive species.
Definitions Subcommittee of the Invasive Species Adivsory Committee
core  

Differential identification of Candida species and other yeasts by analysis of [35S]-methionine-labeled polypeptide profiles. [PDF]

, 2010
[[abstract]]This paper describes a scheme for differential identification of Candida species and other yeasts based on autoradiographic analysis of protein profiles of [35S]methionine-labeled cellular proteins separated by sodium dodecyl sulfate ...
Shen, H. D.;Choo, K. B.;Tsai, W. C.;Jen, T. M.;Yeh, J. Y.; Han, S. H.
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source