Results 91 to 100 of about 188,511 (269)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
The specification language of OBSCURE [PDF]
, 1988 Lehmann, Thomas, Loeckx, Jacques
openaire +1 more source
Programming Language Specification and Implementation
, 2018 The specification of a programming language is a special case of the specification of software in general. This paper discusses the relation between semantics and implementation, or specification and program, using two very different languages for illustration. First, we consider small fragments of a specification of preliminary Ada, and show that what
openaire +3 more sources
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
CASE STUDIES OF CULTURAL COMMUNICATION CONCEPTS EXPRESSED IN THE GERMANIC TERMS FOR ‘SPEECH’. THE HISTORICAL LINGUISTIC BACKGROUND OF A CONCEPT AS GROUND FOR STUDIES IN CONTRASTIVE RHETORIC [PDF]
Studii si Cercetari Filologice: Seria Limbi Straine Aplicate, 2012 This article refers to the studies of ‘contrastive rhetoric’ from a historical perspective examining ‘language contact’-situations of Germanic languages within the IndoEuropean group.
Fee-Alexandra Haase
doaj
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Applications of cognitive theory to interdisciplinary work in Languages for Specific Purposes [PDF]
Ibérica, 1999 Interdisciplinary work is one of the most prominent features in the Language for Specific Purposes (LSP) field. However, little research has been carried out in this area.
Ana María Roldán Riejos
doaj