Results 81 to 90 of about 188,511 (269)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Will we think in programming languages?

open access: yesActa Informatica Pragensia, 2012
Modern science commonly uses computer modelling. Thousands of scientific model are daily transformed to computers programs and tested. The transformation must overcome the gap between abstract human formal notation and low level semantics of contemporary
Jiří Fišer
doaj  

THE U.S. FOREIGN LANGUAGE DEFICIT AND LANGUAGES FOR SPECIFIC PURPOSES [PDF]

open access: yesJournal of Languages for Specific Purposes, 2014
Within the framework of the U.S. foreign language deficit, the author addresses the case for Languages for Specific Purposes (LSP), and more specifically, Business Language Studies (BLS), through an examination of the relevant literature and building on ...
Kathleen Stein-Smith
doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

TEACHING SIGN LANGUAGE FOR HEALTHCARE WITHIN A LANGUAGES FOR SPECIFIC PURPOSES FRAMEWORK [PDF]

open access: yesJournal of Languages for Specific Purposes, 2019
Languages for specific purposes is a subdiscipline of applied linguistics that looks at language learning and teaching for a specific education or training need.
Keren Cumberbatch
doaj  

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Keeping up with the digital age: New data sources in research on languages for specific purposes [PDF]

open access: yesIbérica, 2017
Social media exchanges (for example, via Facebook or Twitter), blogs, and forums, amongst many other electronic genres, have come to be used as relatively bona fide testimonies of language use nowadays.
Amanda Roig-Marín
doaj  

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