Results 81 to 90 of about 278,752 (299)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Specific Learning Disorder -A Life Long Difficulty [PDF]

, 2019
Özgül öğrenme güçlüğü normal ya da normalin üstünde zekâya sahip olduğu halde konuşma, dinleme, okuma, yazma, mantık yürütme ve matematik becerilerinin kaza-nılması ve uygulanmasında zorlukların belirgin olduğu nörobiyolojik bir bozukluktur.
AKSOY, ŞENNUR GÜNAY
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Movement difficulties in children [PDF]

, 2011
The development of adequate motor control and coordination is an important part of general development, allowing an infant to interact with and learn about the world around them and making possible so many everyday activities for children - at home, at ...
Barnett, Anna, Hill, Elisabeth L.
core  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

ADHD IN ADULTS: COMORBODITY WITH BIPOLAR DISORDER AND SUBSTANCE ABUSE [PDF]

, 2011
ADHD is characterized by a continuous history of hyperactivity, forgetfulness, distractibility, impulsiveness and/or inattention, starting from the early childhood and at a more severe extent than whatever may be usual in peers.
CERAUDO, GIUSEPPE
core  

Assessment of Psychiatric Comorbidity and WISC-R Profiles in Cases Diagnosed with Specific Learning Disorder According to DSM-5 Criteria [PDF]

, 2017
National Child and Ergenic Psychiatry Congress -- APR 15, 2016 -- Izmir, TURKEYIntroduction: In this study, the frequency of psychiatric comorbidity in children and adolescents who were diagnosed with specific learning disorder, the factors that affect ...
Menguhan Araz Altay, Altay, Menguhan Araz, Isik Gorker, Gorker, Isik   +3 more
core   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Short-term and working memory in children with specific language impairment [PDF]

, 2006
Investigations of the cognitive processes underlying Specific Language Impairment (SLI) have implicated deficits in the storage and processing of phonological or verbal information.
Archibald, Lisa M. D.
core  

Psychological co-morbidity in children with specific learning disorders

Journal of Family Medicine and Primary Care, 2015
Children under 19 years of age constitute over 40% of India's population and information about their mental health needs is a national imperative. Children with specific learning disorders (SLDs) exhibit academic difficulties disproportionate to their intellectual capacities. Prevalence of SLD ranges from 2% to 10%.
Manoj K Sahoo, Haritha Biswas, Susanta Kumar Padhy   +2 more
openaire   +3 more sources