Results 91 to 100 of about 639,528 (302)
, 2007 In the (mechanical) design process, the requirements specification is a formal registration of the conditions that are imposed on a new or altered product design, both preceding as well as during the corresponding product development cycle. For a long time, the use of technical specifications has prevailed in the establishment of such requirements ...
Miedema, J. +3 more
openaire +1 more source
IMS Content Packaging v1.2 public draft specification
, 2006 The IMS Content Packaging Specification provides the functionality to describe and package learning materials, such as an individual course or a collection of courses, into interoperable, distributable packages.
Vogten, Hubert +2 more
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Guidelines for the development of concrete performance-based specifications in Brazil
Revista IBRACON de Estruturas e MateriaisGuidelines to develop performance specifications of concrete, including suggestions for performance requirements, are presented. This paper proposes changes to the Brazilian specifications and standards in order to follow the international trend and to ...
J. Tanesi, M. G. da Silva, V. Gomes
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
On the Expressive Power of Some Extensions of Linear Temporal Logic
Моделирование и анализ информационных систем, 2018 One of the most simple models of computation which is suitable for representation of reactive systems behaviour is a finite state transducer which operates over an input alphabet of control signals and an output alphabet of basic actions.
Anton Gnatenko, Vladimir Zakharov
doaj +1 more source
The Larch/Smalltalk Interface Specification Language
, 1994 Object-oriented programming languages, such as Smalltalk, help one to build reusable program modules. The reuse of program modules requires adequate documentation --- formal or informal.
Specification Techniques +3 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source