Results 101 to 110 of about 2,598,347 (318)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Specific Friendships

open access: yes, 2018
Friendships among non-kin individuals pose benefits related to survival and reproduction. However, dyadic relationships between any two individuals are not beneficial because of possibilities to exploit others. Selecting partners who are trustworthy is beneficial compared to forming bonds with exploitative partners.
openaire   +2 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Sensitivity and Specificity of Ultrasonography in Diagnosis of Acute Appendicitis

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2009
BACKGROUND AND OBJECTIVE: Acute appendicitis is one of the most important urgent conditions of abdominal surgery, in which, proper and on-time diagnosis may decrease the unwanted complications.
A Mohammadi, F Khodabakhsh
doaj  

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

Reassembling Formal Features in Articles by L1 Persian Learners of L2 English [PDF]

open access: yesApplied Research on English Language, 2015
There has been considerable debate over what the sources of morphological variation in second language acquisition are. From among various hypotheses put forth on the topic, the feature reassembly hypothesis (Lardiere, 2005) assumes that it is the ...
Marjansadat Momenzadeh   +1 more
doaj  

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

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