Results 11 to 20 of about 11,035,091 (298)

Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library

eLife, 2020
Protein-protein interaction specificity is often encoded at the primary sequence level. However, the contributions of individual residues to specificity are usually poorly understood and often obscured by mutational robustness, sequence degeneracy, and ...
Thuy-Lan V Lite, Robert A Grant, Isabel Nocedal, Megan L Littlehale, Monica S Guo, Michael T Laub   +5 more
doaj   +1 more source

Sensitivity, Specificity, and Predictive Values: Foundations, Pliabilities, and Pitfalls in Research and Practice

Frontiers in Public Health, 2017
Within the context of screening tests, it is important to avoid misconceptions about sensitivity, specificity, and predictive values. In this article, therefore, foundations are first established concerning these metrics along with the first of several ...
Robert Trevethan
semanticscholar   +1 more source

Metabolic syndrome: Performance of five different diagnostic criterias

Indian Journal of Endocrinology and Metabolism, 2014
Background: The aim of this study is to describe the metabolic syndrome (MS) and to evaluate five diagnostic criteria of the MS with respect to their sensitivity and specificity in patients with type 2 diabetes mellitus (T2DM).
S Ogedengbe Onesi, U Ezeani Ignatius
doaj   +1 more source

Sodium butyrate attenuates oxidative stress, apoptosis, and excessive mitophagy in sodium fluoride-induced hepatotoxicity in rats

Ecotoxicology and Environmental Safety
Aim: Long-term exposure to excess sodium fluoride (NaF) can cause chronic fluorosis. Liver, the most important detoxification organ, is the most vulnerable to the effects of fluoride.
Jing Xia, Xiaolin Zhang, Leiyu Xu, Nan Yan, Zhenxiang Sun, Xiaoxu Duan, Lu Meng, Rong Qi, Fu Ren, Zhengdong Wang   +9 more
doaj   +1 more source

Comparison of Three Real-Time PCR Assays Targeting the SSU rRNA Gene, the COWP Gene and the DnaJ-Like Protein Gene for the Diagnosis of Cryptosporidium spp. in Stool Samples

Pathogens, 2021
As qualified microscopy of enteric parasitoses as defined by high diagnostic accuracy is difficult to maintain in non-endemic areas due to scarce opportunities for practicing with positive sample materials, molecular diagnostic options provide less ...
Felix Weinreich, Andreas Hahn, Kirsten Alexandra Eberhardt, Torsten Feldt, Fred Stephen Sarfo, Veronica Di Cristanziano, Hagen Frickmann, Ulrike Loderstädt   +7 more
doaj   +1 more source

Multisite Validation of Cryptococcal Antigen Lateral Flow Assay and Quantification by Laser Thermal Contrast

Emerging Infectious Diseases, 2014
Cryptococcal meningitis is common in sub-Saharan Africa. Given the need for data for a rapid, point-of-care cryptococcal antigen (CRAG) lateral flow immunochromatographic assay (LFA), we assessed diagnostic performance of cerebrospinal fluid (CSF ...
David R. Boulware, Melissa A. Rolfes, Radha Rajasingham, Maximilian von Hohenberg, Zhenpeng Qin, Kabanda Taseera, Charlotte Schutz, Richard Kwizera, Elissa K. Butler, Graeme Meintjes, Conrad Muzoora, John C. Bischof, David B. Meya   +12 more
doaj   +1 more source

Validation of the Use of Dried Blood Samples for the Detection of Toxoplasma gondii Antibodies in Stray Cats (Felis s. catus)

Pathogens, 2021
If validated beforehand, the analysis of dried blood on blotting paper (BP samples) is very useful for monitoring free-ranging animals. We aimed to validate this method for the detection of antibodies against Toxoplasma gondii in stray cats.
Julie Alice Simon, Dominique Aubert, Régine Geers, Isabelle Villena, Marie-Lazarine Poulle   +4 more
doaj   +1 more source

Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex

Journal of Neuroscience, 1982
The development of stimulus selectivity in the primary sensory cortex of higher vertebrates is considered in a general mathematical framework. A synaptic evolution scheme of a new kind is proposed in which incoming patterns rather than converging ...
E. Bienenstock, L. Cooper, P. Munro
semanticscholar   +1 more source

Validation of a Commercial Loop-Mediated Isothermal Amplification (LAMP)-Based Kit for the Detection of Salmonella spp. According to ISO 16140:2016

Applied Sciences, 2021
The traditional cultural method (PCR and Real-Time PCR) for Salmonella spp. detection and identification is laborious and time-consuming. A qualitative LAMP method detecting Salmonella spp. was validated in compliance with ISO 16140:2016.
Calogero Di Bella, Antonella Costa, Sonia Sciortino, Giuseppa Oliveri, Gaetano Cammilleri, Francesco Geraci, Daniela Lo Monaco, Davide Carpintieri, Giuseppe Lo Bue, Carmelo Bongiorno, Alessandro Altomare, Valentina Ciprì, Rosario Pitti, Carmine Lanzillo, Giuseppe Arcoleo, Rosalinda Allegro   +15 more
doaj   +1 more source

Specificity, versatility, and control of TGF-β family signaling

Science Signaling, 2019
Molecular function and pathway cross-talk in TGF-β signaling reveal its complexity and open questions. Gloss The transforming growth factor–β (TGF-β) family of secreted proteins is implicated in the control of widely diverse physiologies and its ...
R. Derynck, Erine H. Budi
semanticscholar   +1 more source