Results 71 to 80 of about 96,121 (306)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
MathematicsThe incidence of edges on vertices is a cornerstone of graph theory, with profound implications for various graph properties and applications. Understanding degree distributions and their implications is crucial for analyzing and modeling real-world ...
A. R. Nagalakshmi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
MathematicsIn this paper, three sorts of network indices for the weighted three-layered graph are studied through the methods of graph spectra theory combined with analysis methods.
Jicheng Bian +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Gluing of graph Laplacians and their spectra [PDF]
Linear and Multilinear Algebra, 2018 We study two different types of gluing for graphs: interface (obtained by choosing a common subgraph as the gluing component) and bridge gluing (obtained by adding a set of edges to the given subgraphs). We introduce formulae for computing even and odd Laplacians of graphs obtained by gluing, as well as their spectra.
Contreras, Ivan +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Bounds of the Spectral Radius and the Nordhaus-Gaddum Type of the Graphs
The Scientific World Journal, 2013 The Laplacian spectra are the eigenvalues of Laplacian matrix L(G)=D(G)-A(G), where D(G) and A(G) are the diagonal matrix of vertex degrees and the adjacency matrix of a graph G, respectively, and the spectral radius of a graph G is the largest ...
Tianfei Wang, Liping Jia, Feng Sun
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Mass spectra prediction with structural motif-based graph neural networks
Scientific ReportsMass spectra, which are agglomerations of ionized fragments from targeted molecules, play a crucial role across various fields for the identification of molecular structures.
Jiwon Park, Jeonghee Jo, Sungroh Yoon
doaj +1 more source