Results 111 to 120 of about 235,731 (299)
Electron Acceleration and Time Variability of High Energy Emission from Blazars
, 2000 Blazars are known to emit a broad band emission from radio to gamma-rays with rapid time variations, particularly, in X- and gamma-rays. Synchrotron radiation and inverse Compton scattering are thought to play an important role in emission and the time ...
Coppi P. S. +8 more
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Accelerating Spectral Clustering under Fairness Constraints
ICML ...
Tonin, Francesco +3 more
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin +11 more
wiley +1 more source
A Spectral Acceleration Approach for the Spherical Harmonics Discrete Ordinate Method
Remote Sensing, 2020 A spectral acceleration approach for the spherical harmonics discrete ordinate method (SHDOM) is designed. This approach combines the correlated k-distribution method and some dimensionality reduction techniques applied on the optical parameters of an ...
Adrian Doicu +2 more
doaj +1 more source
The Effect of Coherent Structures on Stochastic Acceleration in MHD Turbulence
, 2005 We investigate the influence of coherent structures on particle acceleration in the strongly turbulent solar corona. By randomizing the Fourier phases of a pseudo-spectral simulation of isotropic MHD turbulence (Re $\sim 300$), and tracing collisionless ...
Achterberg A. +14 more
core +2 more sources
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
Stabilized Radiation Pressure Dominated Ion Acceleration from Thin-foil Targets
, 2010 We study transverse and longitudinal electron heating effects on the target stability and the ion spectra in the radiation pressure dominated regime of ion acceleration by means of multi dimensional particle-in-cell (PIC) simulations.
Alexander Pukhov +3 more
core +1 more source
Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas +39 more
wiley +1 more source
Particle Acceleration at High-$\gamma$ Shock Waves
, 2005 First-order Fermi acceleration processes at ultrarelativistic shocks are studied with Monte Carlo simulations. The accelerated particle spectra are obtained by integrating the exact particle trajectories in a turbulent magnetic field near the shock, with
Niemiec, Jacek
core +2 more sources