Results 121 to 130 of about 539,151 (294)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Research on Fatigue Strength of Polar Icebreaker Structures Considering Ice Loads Based on Discrete Ice Element Model

Journal of Marine Science and Engineering
Structural safety is of utmost importance for polar icebreakers under both navigation and icebreaking conditions. In this research, the Palmgren–Miner linear cumulative damage theory is employed to evaluate the structural fatigue lifespan of polar ...
Lizhi Chen, Zhiyong Pei
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

An efficient spectral method for nonlinear Volterra integro-differential equations with weakly singular kernels

Mathematical Modelling and Analysis
For Volterra integro-differential equations (VIDEs) with weakly singular kernels, their solutions are singular at the initial time. This property brings a great challenge to traditional numerical methods. Here, we investigate the numerical approximation
ZhiPeng Liu, DongYa Tao, Chao Zhang
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A Novel and Effective Scheme for Solving the Fractional Telegraph Problem via the Spectral Element Method

Fractal and Fractional
The combination of fractional derivatives (due to their global behavior) and the challenges related to hyperbolic PDEs pose formidable obstacles in solving fractional hyperbolic equations.
Tao Liu, Runqi Xue, Bolin Ding, Davron A. Juraev, Behzad Nemati Saray, Fazlollah Soleymani   +5 more
doaj   +1 more source

Vibration Analysis of Fluid Conveying Carbon Nanotubes Based on Nonlocal Timoshenko Beam Theory by Spectral Element Method. [PDF]

Nanomaterials (Basel), 2019
Yi X, Li B, Wang Z.
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Implementation of the spectral element discretization of the nonstationary velocity–vorticity–pressure Stokes formulation

Boundary Value Problems
This paper deals with the resolution of the time-dependent velocity–vorticity–pressure formulation of Stokes problem in a two- and three-dimensional domain. The discretization is based on the spectral element method with respect to the space variable and
Nejmeddine Chorfi, Henda Ouertani
doaj   +1 more source

A Crank-Nicolson finite spectral element method for the 2D non-stationary Stokes equations about vorticity-stream functions. [PDF]

J Inequal Appl, 2018
Zhou Y, Luo Z, Teng F.
europepmc   +1 more source