Results 101 to 110 of about 92,516 (310)

Fault severity diagnosis of rolling element bearings based on kurtogram and envelope analysis

open access: yes, 2014
Faults in rolling element bearing are among the main causes of breakdown in rotating machines. Vibration is an effective technique for machine condition monitoring.
Gu, Fengshou   +6 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

On the solution of boundary value problems by the spectral element method

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы, 2015
In spectral element method approximate solution of the original differential operator is found in the form of a combination of the linearly independent system of orthogonal functions on the unit interval.
I.A. Ivanov   +3 more
doaj  

Forced vibration assessment of moderately thick carbon nanotube-reinforced composite plates

open access: yesResults in Physics
Carbon nanotubes, distributed in composite sheets with various arrangements, can lead to the development of materials with functionally graded properties.
Reza Setayesh   +3 more
doaj   +1 more source

The triangular spectral element method for Stokes eigenvalues

open access: yesMathematics of Computation, 2017
A triangular spectral element method is proposed for Stokes eigenvalues, which utilizes the generalized orthogonal Koornwinder polynomials as the local basis functions. The local polynomial projection, which serves as a Fortin interpolation on each triangular element, is defined by the truncated Koornwinder-Fourier series.
Weikun Shan, Huiyuan Li
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Finite element approximation of Maxwell’s equations with Debye memory [PDF]

open access: yes, 2010
Copyright © 2010 Simon Shaw. All rights reserved.This article has been made available through the Brunel Open Access Publishing Fund.Maxwell’s equations in a bounded Debye medium are formulated in terms of the standard partial differential equations of ...
Simon Shaw, Shaw, S
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Damage Detection of A T-Shaped Panel by Wave Propagation Analysis in the Plane Stress / Wykrywanie Uszkodzen W Tarczy Typu T Z Uzyciem Analizy Propagacji Fal W Płaskim Stanie Naprezenia

open access: yesArchives of Civil Engineering, 2012
W pracy zaprezentowano podejscie obliczeniowe do analizy propagacji fal w płaskim stanie naprezenia. Problem brzegowo-poczatkowy podlega przestrzennej aproksymacji z uzyciem wielowezłowych, izoparametrycznych, czworobocznych elementów klasy C0.
Rucka M.   +3 more
doaj   +1 more source

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