Results 81 to 90 of about 13,001,711 (294)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Numerical solution of the viscoelastic wave equation by Galerkin spectral element method [PDF]

Mathematics and Computational Sciences
In this paper, the Galerkin spectral element method (GSEM) is presented for solving the one-dimensional viscoelastic wave equation. The finite difference approximation is applied for temporal discretization, and the convergence order of the technique is ...
Jalil Rashidinia, Feze Barzegar
doaj   +1 more source

Unfitted Spectral Element Method for Interfacial Models

Communications in Computational Physics
In this paper, we propose an unfitted spectral element method for solving elliptic interface and corresponding eigenvalue problems. The novelty of the proposed method lies in its combination of the spectral accuracy of the spectral element method and the flexibility of the unfitted Nitsche’s method.
Nicolas Gonzalez, Hailong Guo, Xu Yang 0018   +2 more
openaire   +3 more sources

p-Multigrid for Fekete Spectral Element Method [PDF]

, 2008
Spectral element approximations based on triangular elements and the so-called Fekete points of the triangle have been recently developed. p-Multigrid methods offer an interesting way to solve efficiently the resulting ill-conditionned algebraic system.
Dolean, Victorita, Pasquetti, Richard, Rapetti, Francesca   +2 more
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Mimetic Spectral Element Method for Anisotropic Diffusion [PDF]

, 2018
This paper addresses the topological structure of steady, anisotropic, inhomogeneous diffusion problems. Two discrete formulations: a) mixed and b) direct formulations are discussed. Differential operators are represented by sparse incidence matrices, while weighted mass matrices play the role of metric-dependent Hodge matrices.
Gerritsma, Marc, Palha, Artur, Jain, Varun, Zhang, Yi   +3 more
openaire   +3 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Structural Damage Detection Using Energy Flow Models

Shock and Vibration, 2008
The presence of a crack in a structure modifies the energy dissipation pattern. As a consequence, damaged structures can present high localized damping.
E.R.O. Santos, V.S. Pereira, J.R.F. Arruda, J.M.C. Dos Santos   +3 more
doaj   +1 more source

Exploring magnetic fluid sensor using dual circular core elliptical cladding photonic crystal fiber

Results in Physics, 2019
The work deals the sensing mechanism of magnetic fluid for various magnetic field strength (Oe). The sensing medium is infiltrated in the given hollow circular hollow channel of photonic crystal fiber(PCF).
Nidal Abulibdeh, K. Vinoth Kumar, C. Karthika, T. Jarin, A. Gopi, Afaf Bouzidi   +5 more
doaj   +1 more source