Results 81 to 90 of about 539,151 (294)
Parallel h-p spectral element method for elliptic problems on polygonal domains [PDF]
, 2002 It is well known that elliptic problems when posed on non-smooth domains, develop singularities. We examine such problems within the framework of spectral element methods and resolve the singularities with exponential ...
Dutt, P. +2 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Exploring magnetic fluid sensor using dual circular core elliptical cladding photonic crystal fiber
Results in Physics, 2019 The work deals the sensing mechanism of magnetic fluid for various magnetic field strength (Oe). The sensing medium is infiltrated in the given hollow circular hollow channel of photonic crystal fiber(PCF).
Nidal Abulibdeh +5 more
doaj +1 more source
A coupled approximate deconvolution and dynamic mixed scale model for large-eddy simulation
, 2007 Large-eddy simulations of incompressible Newtonian fluid flows with approximate deconvolution models based on the van Cittert method are reported. The Legendre spectral element method is used for the spatial discretization to solve the filtered Navier ...
Bouffanais, Roland +3 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Structural Damage Detection Using Energy Flow Models
Shock and Vibration, 2008 The presence of a crack in a structure modifies the energy dissipation pattern. As a consequence, damaged structures can present high localized damping.
E.R.O. Santos +3 more
doaj +1 more source
Spectral element methods for parabolic problems
Journal of Computational and Applied Mathematics, 2007 A spectral element method for parabolic initial value problems on smooth domains using parallel computers is presented. The space domain is divided into a number of regular quadrilaterals of size \(h\) and the time step is proportional to \(h^2\). At each time step we minimize a least-squares functional in different Sobolev norms and a term which ...
Dutt, P., Biswas, P., Ghorai, S.
openaire +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source