Results 71 to 80 of about 539,151 (294)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

A Sparse and High-Order Accurate Line-Based Discontinuous Galerkin Method for Unstructured Meshes

open access: yes, 2012
We present a new line-based discontinuous Galerkin (DG) discretization scheme for first- and second-order systems of partial differential equations.
Persson, Per-Olof
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The Penalty resolution of the spectral element discretization of the time dependent Darcy equations

open access: yesBoundary Value Problems
The time-dependent Darcy system, when discretized in time using the implicit Euler scheme and in space using the spectral element method, can be efficiently solved using the penalty method.
Nejmeddine Chorfi   +2 more
doaj   +1 more source

An improved spectral decomposition flexibility perturbation method for finite element model updating

open access: yesAdvances in Mechanical Engineering, 2018
Finite element analysis is the most powerful tool to predict the behavior of a structure in engineering practice. Generally, the initial finite element model must be corrected with experimental data due to its complexity.
QW Yang, BX Sun, C Lu
doaj   +1 more source

Nonconforming Schwarz-spectral element methods for incompressible flow [PDF]

open access: yesComputers & Fluids, 2019
We present scalable implementations of spectral-element-based Schwarz overlapping (overset) methods for the incompressible Navier-Stokes (NS) equations. Our SEM-based overset grid method is implemented at the level of the NS equations, which are advanced independently within separate subdomains using interdomain velocity and pressure boundary-data ...
Ketan Mittal, Som Dutta, Paul Fischer
openaire   +3 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Optimal Error Estimates of Galerkin Finite Element Methods for Stochastic Partial Differential Equations with Multiplicative Noise

open access: yes, 2011
We consider Galerkin finite element methods for semilinear stochastic partial differential equations (SPDEs) with multiplicative noise and Lipschitz continuous nonlinearities.
Kruse, Raphael
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Numerical solution of the viscoelastic wave equation by Galerkin spectral element method [PDF]

open access: yesMathematics and Computational Sciences
In this paper, the Galerkin spectral element method (GSEM) is presented for solving the one-dimensional viscoelastic wave equation. The finite difference approximation is applied for temporal discretization, and the convergence order of the technique is ...
Jalil Rashidinia, Feze Barzegar
doaj   +1 more source

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