Results 71 to 80 of about 13,001,711 (294)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Boundary Value Problems, 2019 We propose to implement the mortar spectral elements discretization of the heat equation in a bounded two-dimensional domain with a piecewise continuous diffusion coefficient. The discretization on time is based on the Euler implicit method.
Mohamed Abdelwahed, Nejmeddine Chorfi
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
An improved spectral decomposition flexibility perturbation method for finite element model updating
Advances in Mechanical Engineering, 2018 Finite element analysis is the most powerful tool to predict the behavior of a structure in engineering practice. Generally, the initial finite element model must be corrected with experimental data due to its complexity.
QW Yang, BX Sun, C Lu
doaj +1 more source
High-Order Methods Applied to Nonlinear Magnetostatic Problems
Mathematical and Computational Applications, 2019 This paper presents a comparison between two high-order modeling methods for solving magnetostatic problems under magnetic saturation, focused on the extraction of machine parameters.
Léo A. J. Friedrich +3 more
doaj +1 more source
Spectral Volume Method: application to Euler equations and performance appraisal [PDF]
, 2010 The compact high-order "Spectral Volume Method" designed for conservation laws on unstructured grids is presented. Its spectral reconstruction is exposed briefly and its applications to the Euler equations are presented through several test cases to ...
Chikhaoui, Oussama +2 more
core
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Penalty resolution of the spectral element discretization of the time dependent Darcy equations
Boundary Value ProblemsThe time-dependent Darcy system, when discretized in time using the implicit Euler scheme and in space using the spectral element method, can be efficiently solved using the penalty method.
Nejmeddine Chorfi +2 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source