Results 51 to 60 of about 181,754 (235)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The NIRSPEC Brown Dwarf Spectroscopic Survey II: High-Resolution J-Band Spectra of M, L and T Dwarfs [PDF]

, 2006
We present a sequence of high resolution (R~20,000 or 15 km/s) infrared spectra of stars and brown dwarfs spanning spectral types M2.5 to T6. Observations of 16 objects were obtained using eight echelle orders to cover part of the J-band from 1.165-1.323
Adam J. Burgasser, Delfosse X., Emily L. Rice, Ian S. McLean, J. Davy Kirkpatrick, Jones H. R. A., Jones H. R. A., L. Prato, Mark R. McGovern, Sungsoo S. Kim   +9 more
core   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Comparison Between Hitran2012 Data And A New Experimental Line List Recently Published For Water Vapor In The Spectral Region 6450 To 9400 Cm⁻¹

, 2014
Recently an experimental list of water absorption lines between 6450 and 9400 cm−1 has been published by Régalia et al.1 This paper includes detailed comparison with HITRAN20082 and GEISA20093 databases. Before the end of the redaction of this article1, the new version of the HITRAN database4 was published.
Mikhailenko, S., Régalia, L.
openaire   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

IRAS 18511+0146: a proto Herbig Ae/Be cluster? [PDF]

, 2007
Context: The evolution of a young protocluster depends on the relative spatial distributions and dynamics of both stars and gas. Aims: We study the distribution and properties of the gas and stars surrounding the luminous (10^4 L_sun) protocluster IRAS ...
A. Noriega-Crespo, Allen, Baraffe, Benjamin, Bianchi, Brand, Cohen, Fazio, Furlan, Habart, Hildebrand, Hunt, Indebetouw, Ishii, Johnston, Keto, Kurtz, L. Testi, Lada, Lada, M. Walmsley, Meyer, Molinari, Molinari, Molinari, Palla, Panagia, Persson, Plambeck, Rieke, Rieke, Robitaille, S. Carey, S. Molinari, S. Vig, Schraml, Testi, Testi, Testi, Wang, Watt, Weidner, Werner, Whittet, Zhang   +44 more
core   +3 more sources

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

5-micron photometry of late-type dwarfs [PDF]

, 2001
We present narrowband-M photometry of nine low-mass dwarfs with spectral types ranging from M2.5 to L0.5. Combining the (L'-M') colours derived from our observations with data from the literature, we find colours consistent with a Rayleigh-Jeans flux ...
Berriman G., I. Neill Reid, Johnson H. L., Jones H. R. A., K. L. Cruz, Reid I. N., Sinton W. M., Tsuji T., Wehrse R.   +8 more
core   +3 more sources

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer, Simon Faissner, Ralf Gold, Aiden Haghikia   +3 more
wiley   +1 more source