Results 71 to 80 of about 5,361,465 (264)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Visible Opacities of S-type Stars: The d 3Φ–a 3Δ Band System of ZrO
The Astrophysical JournalZrO is a well-studied metal monoxide because of its astrophysical importance in characterizing S stars. The bands of the d ^3 Φ–a ^3 Δ system ( γ system) with ${v}^{{\prime} }\leqslant 4$ and v ″ ≤ 5 are rotationally analyzed using the PGOPHER program to
Peter F. Bernath +2 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
The A2Π–X2Σ+ Band System of YO
The Astrophysical JournalYO bands are conspicuous in the spectra of S stars. The laboratory spectrum of the A ^2 Π–X ^2 Σ ^+ electronic transition has been recorded with a Fourier transform spectrometer using a composite-wall hollow cathode lamp source.
Peter F Bernath +2 more
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
EXPERIMENTAL LINE LISTS OF HOT METHANE [PDF]
Line lists of CH$_{4}$ at high temperatures (up to 900$^{circ}$C) have been produced between 2500 and 5000 cm$^{-1}$. This spectral range contains the pentad and octad regions, and includes numerous fundamental, overtone and hot bands.
Hargreaves, Robert J.
core
Comprehensive Ab Initio Quantum Computations of CO2–H2 and CO2–He Collisional Properties
The Astrophysical JournalWe present comprehensive ab initio fully quantum calculations of CO _2 –H _2 and CO _2 –He collisional properties. Our framework combines CCSD(T) potential-energy-surface calculations with close-coupling dynamical scattering in the Yumi framework to ...
Prajwal Niraula +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
A Test of FeH Line Parameters Using DR19 APOGEE Spectra of Benchmark M Dwarfs
The Astrophysical JournalRecent studies have suggested a mismatch of up to 0.20 dex between iron abundances derived from Fe I and FeH lines in the H -band spectra of M dwarfs and in this work we investigate the nature of this possible offset.
Anderson Silva-Andrade +11 more
doaj +1 more source