Results 41 to 50 of about 165,880 (282)

A Prismatic Analyser concept for Neutron Spectrometers [PDF]

open access: yes, 2014
A development in modern neutron spectroscopy is to avoid the need of large samples. We demonstrate how small samples together with the right choice of analyser and detector components makes distance collimation an important concept in crystal analyser ...
Birk, Jonas O.   +9 more
core   +4 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Design and Development of Dipole Magnet for MIR/THz Free Electron Laser Beam Dumps and Spectrometers

open access: yesParticles
This study presents the design and development of electromagnetic dipole magnets for use as beam dumps and spectrometers in the MIR and THz free-electron laser (FEL) beamlines at the PBP-CMU Electron Linac Laboratory (PCELL).
Ekkachai Kongmon   +4 more
doaj   +1 more source

Review of Miniaturized Computational Spectrometers

open access: yesSensors, 2023
Spectrometers are key instruments in diverse fields, notably in medical and biosensing applications. Recent advancements in nanophotonics and computational techniques have contributed to new spectrometer designs characterized by miniaturization and ...
Qingze Guan   +4 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

An inversely designed integrated spectrometer with reconfigurable performance and ultra-low power consumption

open access: yesOpto-Electronic Advances
Despite the pressing demand for integrated spectrometers, a solution that deliver high-performance while being practically operated is still missing.
Ang Li   +5 more
doaj   +1 more source

Characteristic Analysis of Compact Spectrometer Based on Off-Axis Meta-Lens

open access: yesApplied Sciences, 2018
Ultra-compact spectrometers with high-resolution and/or broadband features have long been pursued for their wide application prospects. The off-axis meta-lens, a new species of planar optical instruments, provides a unique and feasible way to realize ...
Yi Zhou, Rui Chen, Yungui Ma
doaj   +1 more source

Qubits as spectrometers of dephasing noise

open access: yes, 2011
We present a procedure for direct characterization of the dephasing noise acting on a single qubit by making repeated measurements of the qubit coherence under suitably chosen sequences of controls.
C. Cohen-Tannoudji   +6 more
core   +1 more source

Characterization of digital dispersive spectrometers by low coherence interferometry [PDF]

open access: yes, 2017
We propose a procedure to determine the spectral response of digital dispersive spectrometers without previous knowledge of any parameter of the system.
Izquierdo, J. G.   +4 more
core   +2 more sources

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