Results 61 to 70 of about 79,504 (299)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

The performance of consumer-grade near infrared spectrometer in traditional Chinese medicine

Journal of the European Optical Society-Rapid Publications, 2020
Technical advances in instrument manufacturing have promoted the miniaturization and cost reduction of portable NIR spectrometers. The price of a device is now affordable to ordinary consumers, which might promotes the application of NIRS in real ...
Zhaozhou Lin, Zhihong Zhuang, Chongnian Luo, Jiayu Zhang, Hao Gu   +4 more
doaj   +1 more source

Evaluating the Capability of Low-Configuration Spectrometers to Retrieve Far-Red Solar-Induced Chlorophyll Fluorescence and Its Application for Identifying Crop Growth Stages

Journal of Remote Sensing
The ground-based continuous hyperspectral remote sensing technique presents a unique opportunity to advance terrestrial ecosystem monitoring. Accurate retrieval of solar-induced chlorophyll fluorescence (SIF) relies heavily on commercially available ...
Lei Pei, Yongguang Zhang, Zhaoying Zhang, Yunfei Wu, Yuqing Hou, Linsheng Wu   +5 more
doaj   +1 more source

Calibration and instrumental line shape characterization of a set of portable FTIR spectrometers for detecting greenhouse gas emissions [PDF]

Atmospheric Measurement Techniques, 2015
A comprehensive calibration procedure for mobile, low-resolution, solar-absorption FTIR spectrometers, used for greenhouse gases observations, is developed. These instruments commend themselves for campaign use and deployment at remote sites.
M. Frey, F. Hase, T. Blumenstock, J. Groß, M. Kiel, G. Mengistu Tsidu, K. Schäfer, M. K. Sha, J. Orphal   +8 more
doaj   +1 more source

The GRAVITY spectrometers: mechanical design

, 2010
Operating on 6 interferometric baselines, i.e. using all 4 UTs, the 2nd generation VLTI instrument GRAVITY will deliver narrow angle astrometry with 10μas accuracy at the infrared K-band.
Fischer, Sebastian, Brandner, Wolfgang, Fischer, S., Brandner, W., Perraut, K., Antonio Amorim, Andreas Eckart, Eckart, A., Karine Perraut, Eisenhauer, Frank, Wiest, Michael, Araujo-Hauck, Constanza, Markus Schöller, Yazici, S., Christian Straubmeier, Schöller, M., Constanza Araujo-Hauck, Araujo-Hauck, C., Schöller, Markus, Perraut, Karine, Eisenhauer, F., Frank Eisenhauer, Amorim, A., Senol Yazici, Amorim, Antonio, Wolfgang Brandner, Straubmeier, Christian, Straubmeier, C., Guy Perrin, Wiest, M., Yazici, Senol, Perrin, Guy, Sebastian Fischer, Michael Wiest, Eckart, Andreas, Perrin, G.   +35 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Integrating artificial intelligence with miniature mass spectrometry

Green Analytical Chemistry
Miniature mass spectrometers are increasingly being employed in various analytical fields due to their portability and low cost. Unlike lab-scale mass spectrometers, miniature mass spectrometers typically operate in environments that demand more ...
Jiayi Wang, Lingyan Liu, Ting Jiang
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

i-PHAOS: An Overview with an Open-Source Collaborative Database on Miniaturized Integrated Spectrometers

Sensors
On-chip spectrometers are increasingly becoming tools that might help in everyday life needs. The possibility offered by several available integration technologies and materials to be used to miniaturize spectrometers has led to a plethora of very ...
Carla Maria Coppola, Martino De Carlo, Francesco De Leonardis, Vittorio M. N. Passaro   +3 more
doaj   +1 more source