Results 81 to 90 of about 372,055 (343)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Spectrometers for compact neutron sources [PDF]

, 2018
We discuss the potential for neutron spectrometers at novel accelerator driven compact neutron sources. Such a High Brilliance Source (HBS) relies on low energy nuclear reactions, which enable cryogenic moderators in very close proximity to the target ...
J. Voigt, Brückel, Thomas, T. Brückel, Rücker, U., T. Gutberlet, J.P. Dabruck, Dabruck, J. P., Voigt, Jörg, Rücker, Ulrich, S. Böhm, U. Rücker, Böhm, Sarah, Voigt, J., Gutberlet, T., Böhm, S., Brückel, T., Dabruck, Jan-Philipp   +16 more
core   +1 more source

The GRETINA Spectrometer

Journal of Physics: Conference Series, 2013
The GRETINA spectrometer is a first generation, gamma-ray tracking spectrometer capable of determining the Compton scattering path of gamma-rays incident on the detector volume. This ability allows the Ge detectors to be close packed allowing the detector to be scaled to high efficiencies while maintaining good peak-to-total. GRETINA currently consists
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Prospector: A mobile application for portable, high‐throughput near‐infrared spectroscopy phenotyping

Plant Phenome Journal, 2021
Quality traits are some of the most important and time‐consuming phenotypes to evaluate in plant breeding programs. These traits are often evaluated late in the breeding pipeline due to their cost, resulting in the potential advancement of many lines ...
Trevor W. Rife, Chaney Courtney, Jenna Hershberger, Michael Allen Gore, Mitchell Neilsen, Jesse Poland   +5 more
doaj   +1 more source

The Atmospheric Chemistry Suite (ACS) of Three Spectrometers for the ExoMars 2016 Trace Gas Orbiter

, 2018
The Atmospheric Chemistry Suite (ACS) package is an element of the Russian contribution to the ESA-Roscosmos ExoMars 2016 Trace Gas Orbiter (TGO) mission.
O. Korablev, F. Montmessin, A. Trokhimovskiy, A. Fedorova, A. Shakun, A. Grigoriev, B. Moshkin, N. Ignatiev, F. Forget, F. Lefévre, K. Anufreychik, I. Dzuban, Y. Ivanov, Y. K. Kalinnikov, T. Kozlova, A. Kungurov, V. Makarov, F. Martynovich, I. Maslov, D. Merzlyakov, P. Moiseev, Y. Nikolskiy, A. Patrakeev, D. Patsaev, A. Santos-Skripko, O. Sazonov, N. Semena, A. Semenov, V. Shashkin, A. Sidorov, A. Stepanov, I. Stupin, D. Timonin, A. Titov, A. Viktorov, A. Zharkov, F. Altieri, G. Arnold, D. Belyaev, J. Bertaux, D. Betsis, N. Duxbury, T. Encrenaz, T. Fouchet, J. Gérard, D. Grassi, S. Guerlet, P. Hartogh, Y. Kasaba, I. Khatuntsev, V. Krasnopolsky, V. Krasnopolsky, R. Kuzmin, E. Lellouch, M. López‐Valverde, M. Luginin, A. Määttänen, E. Marcq, J. Torres, A. Medvedev, E. Millour, K. Olsen, Manish R. Patel, C. Quantin‐Nataf, A. Rodin, A. Rodin, V. Shematovich, I. Thomas, N. Thomas, L. Vázquez, M. Vincendon, V. Wilquet, Colin F. Wilson, L. Zasova, L. Zelenyi, M. Zorzano   +75 more
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

NOMAD, an Integrated Suite of Three Spectrometers for the ExoMars Trace Gas Mission: Technical Description, Science Objectives and Expected Performance

Space Science Reviews, 2018
The NOMAD (“Nadir and Occultation for MArs Discovery”) spectrometer suite on board the ExoMars Trace Gas Orbiter (TGO) has been designed to investigate the composition of Mars’ atmosphere, with a particular focus on trace gases, clouds and dust.
A. Vandaele, J. Lopez‐Moreno, Manish R. Patel, Manish R. Patel, G. Bellucci, F. Daerden, B. Ristic, S. Robert, I. Thomas, V. Wilquet, M. Allen, G. Alonso-Rodrigo, F. Altieri, S. Aoki, D. Bolsée, T. Clancy, E. Cloutis, C. Depiesse, R. Drummond, A. Fedorova, V. Formisano, B. Funke, F. González-Galindo, A. Geminale, J. Gérard, M. Giuranna, L. Hetey, N. Ignatiev, J. Kaminski, Ö. Karatekin, Y. Kasaba, M. Leese, F. Lefévre, S. Lewis, M. López‐Puertas, M. López‐Valverde, A. Mahieux, A. Mahieux, J. Mason, J. McConnell, M. Mumma, L. Neary, E. Neefs, E. Renotte, J. Rodríguez-Gómez, G. Sindoni, M. Smith, A. Stiepen, A. Trokhimovsky, J. Auwera, G. Villanueva, G. Villanueva, S. Viscardy, J. Whiteway, Y. Willame, M. Wolff   +55 more
semanticscholar   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Measurement of Mixed Biomass Burning and Mineral Dust Aerosol in the Thermal Infrared [PDF]

, 2008
From January 19th to February 7th, 2008, we installed a Fourier transform infrared spectrometer (FTIR) at Praia Airport on the island of Santiago, Cape Verde. Our goal was to measure the combined radiative effect of biomass burning aerosol and mineral
Lindermeir, Erwin, Köhler, Claas, Trautmann, Thomas   +2 more
core