Results 51 to 60 of about 79,504 (299)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

An inversely designed integrated spectrometer with reconfigurable performance and ultra-low power consumption

Opto-Electronic Advances
Despite the pressing demand for integrated spectrometers, a solution that deliver high-performance while being practically operated is still missing.
Ang Li, Yifan Wu, Chang Wang, Feixia Bao, Zongyin Yang, Shilong Pan   +5 more
doaj   +1 more source

Characteristic Analysis of Compact Spectrometer Based on Off-Axis Meta-Lens

Applied Sciences, 2018
Ultra-compact spectrometers with high-resolution and/or broadband features have long been pursued for their wide application prospects. The off-axis meta-lens, a new species of planar optical instruments, provides a unique and feasible way to realize ...
Yi Zhou, Rui Chen, Yungui Ma
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Prospector: A mobile application for portable, high‐throughput near‐infrared spectroscopy phenotyping

Plant Phenome Journal, 2021
Quality traits are some of the most important and time‐consuming phenotypes to evaluate in plant breeding programs. These traits are often evaluated late in the breeding pipeline due to their cost, resulting in the potential advancement of many lines ...
Trevor W. Rife, Chaney Courtney, Jenna Hershberger, Michael Allen Gore, Mitchell Neilsen, Jesse Poland   +5 more
doaj   +1 more source

The Miniball spectrometer [PDF]

The European Physical Journal A, 2013
The Miniball germanium detector array has been operational at the REX (Radioactive ion beam EXperiment) post accelerator at the Isotope Separator On-Line facility ISOLDE at CERN since 2001. During the last decade, a series of successful Coulomb excitation and transfer reaction studies have been performed with this array, utilizing the unique and high ...
Cocolios, Thomas, Warr, N., Van de Walle, J., Albers, M., Ames, F., Bastin, B., Bauer, C., Bildstein, V., Blazhev, A., Bönig, S., Bree, N., Bruyneel, B., Butler, P. A., Cederkäll, J., Clément, E., Cocolios, T. E., Davinson, T., De Witte, H., Delahaye, P., DiJulio, D. D., Diriken, J., Eberth, J., Ekström, A., Elseviers, J., Emhofer, S., Fedorov, D. V., Fedosseev, V. N., Franchoo, S., Fransen, C., Gaffney, L. P., Gerl, J., Georgiev, G., Gernhäuser, R., Grahn, T., Habs, D., Hess, H., Hurst, A. M., Huyse, M., Ivanov, O., Iwanicki, J., Jenkins, D. G., Jolie, J., Kesteloot, N., Kester, O., Köster, U., Krauth, M., Kröll, T., Krücken, R., Lauer, M., Leske, J., Lieb, K. P., Lutter, R., Maier, L., Marsh, B. A., Mücher, D., Münch, M., Niedermaier, O., Pakarinen, J., Pantea, M., Pascovici, G., Patronis, N., Pauwels, D., Petts, A., Pietralla, N., Raabe, R., Rapisarda, E., Reiter, P., Richter, A., Schaile, O., Scheck, M., Scheit, H., Schrieder, G., Schwalm, D., Seidlitz, M., Seliverstov, M., Sieber, T., Simon, H., Speidel, K. H., Stahl, C., Stefanescu, I., Thirolf, P. G., Thomas, H. G., Thürauf, M., Van Duppen, P., Voulot, D., Wadsworth, R., Walter, G., Weißhaar, D., Wenander, F., Wiens, A., Wimmer, K., Wolf, B. H., Woods, P. J., Wrzosek-Lipska, K., Zell, K. O.   +94 more
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source