Results 51 to 60 of about 165,880 (282)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Momentum-resolved resonant inelastic soft X-ray scattering (qRIXS) endstation at the ALS [PDF]

, 2019
A momentum resolved resonant inelastic X-ray scattering (qRIXS) experimental station with continuously rotatable spectrometers and parallel detection is designed to operate at different beamlines at synchrotron and free electron laser (FEL) facilities ...
Brown, Adam,, Chen, Yu Jen,, Chuang, Yi De,, Cruz, Alejandro,, Devereaux, Thomas P.,, Duarte, Robert,, Feng, Xuefei,, Frano, Alex,, Gullikson, E.,, Guo, Jinghua,, Hanzel, Kelly,, Huang, Shih Wen,, Hussain, Zahid,, Kim, Jaemyung,, Lee, Wei Sheng,, Lund University., Pepper, John S.,, Shao, Yu Cheng,, Shen, Zhi Xun,, Smith, Brian,, Spucces, Adrian,, Tremsin, Anton, Wray, L. Andrew,, Yang, Wanli,   +23 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Prospector: A mobile application for portable, high‐throughput near‐infrared spectroscopy phenotyping

Plant Phenome Journal, 2021
Quality traits are some of the most important and time‐consuming phenotypes to evaluate in plant breeding programs. These traits are often evaluated late in the breeding pipeline due to their cost, resulting in the potential advancement of many lines ...
Trevor W. Rife, Chaney Courtney, Jenna Hershberger, Michael Allen Gore, Mitchell Neilsen, Jesse Poland   +5 more
doaj   +1 more source

Astronomical spectrograph calibration with broad-spectrum frequency combs

, 2008
Broadband femtosecond-laser frequency combs are filtered to spectrographically resolvable frequency-mode spacing, and the limitations of using cavities for spectral filtering are considered. Data and theory are used to show implications to spectrographic
26, 380, Abedin, Bartels, Bartels, Ciddor, D. A. Braje, DeVoe, Dudley, Fortier, Fortier, Hall, Hansch, Jones, Kumar, Li, M. S. Kirchner, Marcy, McFerran, Meyer, Nicholson, Pal, Ranka, S. A. Diddams, S. Osterman, Schliesser, Sizer, Stone, T. Fortier, Tauser, Udem, Udem, Washburn, Yiannopoulos   +33 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

High-resolution and broadband all-fiber spectrometers

, 2014
The development of optical fibers has revolutionized telecommunications by enabling long-distance broad-band transmission with minimal loss. In turn, the ubiquity of high-quality low-cost fibers enabled a number of additional applications, including ...
Alam, Mansoor, Cao, Hui, Redding, Brandon, Seifert, Martin   +3 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The performance of consumer-grade near infrared spectrometer in traditional Chinese medicine

Journal of the European Optical Society-Rapid Publications, 2020
Technical advances in instrument manufacturing have promoted the miniaturization and cost reduction of portable NIR spectrometers. The price of a device is now affordable to ordinary consumers, which might promotes the application of NIRS in real ...
Zhaozhou Lin, Zhihong Zhuang, Chongnian Luo, Jiayu Zhang, Hao Gu   +4 more
doaj   +1 more source

Apparatus and method for characterizing the transmission efficiency of a mass spectrometer [PDF]

, 1990
An electron/ion coincidence technique is employed to characterize the absolute mass dependent transmission efficiency of mass spectrometers. The technique is not dependent upon the partial pressure of the sample beam or the ionization cross sections of ...
Srivasytava, Santash
core   +1 more source