Results 31 to 40 of about 193,200 (241)
Trapping and sympathetic cooling of conformationally selected molecular ions [PDF]
arXiv, 2023 We report the generation, trapping and sympathetic cooling of individual conformers of molecular ions with the example of cis- and trans-meta-aminostyrene. Following conformationally selective photoionization, the incorporation of the conformers into a Coulomb crystal of laser-cooled calcium ions was confirmed by fluorescence imaging, mass spectrometry
arxiv
Frontiers in Analytical Science, 2023 Ratiometric strategy are an invaluable method that helps to detect and quantify analytes. This approach relies on measuring changes in the ratio of two or more signals to improve the accuracy and sensitivity of the results.
Manivannan Madhu +4 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Parallel G-duplex and C-duplex DNA with Uninterrupted Spines of AgI-Mediated Base Pairs [PDF]
J. Phys. Chem. Lett. (2018) 9(22): 6605-6610, 2018 Hydrogen bonding between nucleobases produces diverse DNA structural motifs, including canonical duplexes, guanine (G) quadruplexes and cytosine (C) i-motifs. Incorporating metal-mediated base pairs into nucleic acid structures can introduce new functionalities and enhanced stabilities.
arxiv +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Yankuang ceshi, 2022 BACKGROUND Selenium (Se) is one of the essential trace elements for humans, and an important way for humans to obtain and supplement selenium is by eating natural selenium-enriched agricultural products. The geochemical characteristics of selenium in the
ZHAO Chen +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu +3 more
wiley +1 more source
Scientia Agricola, 2013 Nutrient analysis is used to estimate nutrient content of crop plants to manage fertilizer application for sustained crop production. Direct solid analysis of agricultural and environmental samples by energy dispersive X-ray fluorescence spectrometry ...
Tiago Tezotto +5 more
doaj +1 more source
Novel EDTA-Ligands Containing an Integral Perylene Bisimide (PBI) Core as Optical Reporter Unit [PDF]
Org. Biomol. Chem. 2014, 12, 7045-7058, 2018 The synthesis, characterization and metal complexation of a new class of perylene bisimides (PBIs) being an integral part of ethylenediaminetetraacetic acid (EDTA) is reported. The simplest representative, namely derivative 1a, was synthesized both by a convergent as well as a direct approach while the elongated derivatives, 1b and 1c, were obtained ...
arxiv +1 more source